Author

K. Rox

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 2 Organism:bacteria (other)· 1 Assay:CRISPR screen· 1 Approach:deep learning· 1 Organism:human· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

A. Boudrioua· 1 shared A. Chen· 1 shared A. Dmitriev· 1 shared A. Flieger· 1 shared A. Ganapathysamy· 1 shared A. Kohler· 1 shared A. Krishnan· 1 shared A. Morejon Morales· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperMicrobiology

A. Boudrioua

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Identification of targetable vulnerabilities of PLK1-overexpressing cancers by synthetic dosage lethality

C. E. Cunningham, F. S. Vizeacoumar, Y. Zhang, L. Kyrylenko, P. Gao, V. Maranda, H. Dong, J. D. Price, A. Ganapathysamy, R. Hari, C. Denomy, S. Both, K. Wagner, Y. Wu, F. Khan, , M. Empting

The paper identifies synthetic dosage lethality targets for PLK1-overexpressing cancers using genome-wide screens and validates key hits to show their therapeutic potential.

Cell Genomics · Jun 1, 2025Peer-reviewedCancer Biology

Discovery of a synthetic small molecule targeting the central regulator of Salmonella pathogenicity

A. Boudrioua, J. D. Joiner, I. Grin, T. Kronenberger, V. S. Korotkov, W. Steinchen, A. Kohler, S. Schminke, J.-C. Schulte, M. Pietsch, A. Naini, S. Kalverkamp, S.-K. Hotop, T. Coyle, C. Piselli, , S. Wagner

The paper identifies a synthetic small molecule, C26, that inhibits HilD, a key regulator of Salmonella secretion systems, thereby preventing bacterial invasion of host cells.

bioRxiv · Apr 29, 2024 · PreprintMicrobiology

X-ray Structure of Main Protease of the Novel Coronavirus SARS-CoV-2 Enables Design of α-Ketoamide Inhibitors

L. Zhang, D. Lin, X. Sun, K. Rox, R. Hilgenfeld

The paper determines the X-ray structure of SARS-CoV-2 main protease and uses it to design alpha-ketoamide inhibitors with improved pharmacokinetic properties.

bioRxiv · Feb 17, 2020 · PreprintBiochemistry