B. Pan

An extinct clade sister to Eumetazoa: On the phylogeny of the Cambrian chancelloriids

This study describes new fossils of chancelloriids, revealing their unique body plan and suggesting they are a basal clade sister to eumetazoans.

Meiosis-specific decoupling of the pericentromere from the kinetochore

The paper identifies a meiosis-specific pericentromere specification in Peromyscus mouse oocytes that separates sister-chromatid cohesion from the kinetochore.

PI3Kγ promotes neutrophil extracellular trap formation by noncanonical pyroptosis in abdominal aortic aneurysm

This study identifies PI3Kγ as a regulator of neutrophil extracellular trap formation in abdominal aortic aneurysm via noncanonical pyroptosis, showing its inhibition reduces inflammation and ameliorates AAA.

The membrane curvature inducing REEP1 proteins generate a novel ER-derived vesicular compartment

This study identifies REEP1 proteins as forming a novel ER-derived vesicular compartment and shows that mutations affecting their curvature-inducing activity lead to relocalization to the bulk ER.

Structure basis for recognition of 26RFa by the pyroglutamylated RFamide peptide receptor

This study determines the cryo-EM structure of QRFPR bound to 26RFa, revealing the recognition mechanism and aiding drug design for obesity and diabetes.

Evolution and diversity of biomineralized columnar architecture in early Cambrian phosphatic-shelled brachiopods

This study reports well-preserved columnar shell ultrastructures in early Cambrian brachiopods, revealing their biomineralization processes and evolutionary significance.

Semi-synthetic CoA-alpha-Synuclein Constructs Trap N-terminal Acetyltransferase NatB for Binding Mechanism Studies

This study creates a semi-synthetic inhibitor of NatB using coenzyme A and full-length alpha-synuclein, revealing structural and conformational changes upon binding.

Dying cell-released exosomal CXCL1 promotes breast cancer metastasis by activating TAM/PD-L1 signaling

This study shows that exosomal CXCL1 from dying breast cancer cells promotes metastasis by activating TAM/PD-L1 signaling and identifies TPCA-1 as a potential inhibitor.

Single-cell transcriptome analysis on the anatomic positional heterogeneity of pig skin

The paper analyzes single-cell transcriptomes of pig skin from six anatomical regions to characterize cellular heterogeneity and identify candidate genes for ECM accumulation.

A reversible SRC-relayed COX2-inflammatory program drives therapeutic resistance in BRAF(V600E) colorectal tumors

This study identifies a SRC-relayed COX2-inflammatory program that drives resistance to BRAF/MEK/EGFR therapies in BRAFV600E colorectal tumors and shows that co-targeting COX2 improves therapeutic outcomes.

Study on the interference of DicdsVg4 and DicdsVgR in egg formation in the ovary of Diaphorina citri (Kuwayama)

This study shows that interfering with DicVg4 and DicVgR genes in Diaphorina citri reduces vitellogenin accumulation, prevents normal egg formation, and leads to abnormal eggs and nymphs.

Mechanical gating of the auditory transduction channel TMC1 involves the fourth and sixth transmembrane helices

The paper investigates how mutations in TM4 and TM6 helices of TMC1 affect mechanical gating of auditory transduction channels in hair cells.

Long noncoding RNA VENTHEART is required for cardiomyocyte specification and function

This study identifies VENTHEART as a lncRNA essential for cardiomyocyte specification, maturation, and function, with potential relevance to heart disease.

Molecular mechanism of N-terminal acetylation by the ternary NatC complex

The paper reports the Cryo-EM structure of S. pombe NatC complex and identifies IP6 as a stabilizer, revealing substrate specificity overlaps with NatE.

Molecular Basis for N-terminal Alpha-Synuclein Acetylation by Human NatB

The paper reports the cryo-EM structure of hNatB bound to a CoA-Syn conjugate and analyzes mutational effects on catalysis, revealing substrate-specific recognition mechanisms.

The Calcineurin-TFEB-p62 Pathway Mediates the Activation of Cardiac Macroautophagy by Proteasomal Malfunction

This study identifies the Mocln1-calcineurin-TFEB-p62 pathway as mediating cardiac macroautophagy activation due to proteasomal malfunction.

Duo-activation of PKA and PKG by PDE1 inhibition facilitates proteasomal degradation of misfolded proteins and protects against proteinopathy

PDE1 inhibition enhances proteasomal degradation of misfolded proteins via PKA and PKG activation, reducing cardiac proteinopathy and HFpEF in CryABR120G mice.