R. Marmorstein

Molecular Basis for RNA Cytidine Acetylation by NAT10

This study determines the cryo-EM structure of NAT10 bound to a cytidine-CoA probe, revealing its mechanism for RNA N4-cytidine acetylation and its role in cellular processes.

Engineering Substrate Channeling in Assembly-Line Terpene Biosynthesis

This study shows that substrate channeling in PaFS occurs without a flexible linker or covalent domain linkage, and that cyclase domains associate with the prenyltransferase octamer for optimal channeling.

Semi-synthetic CoA-alpha-Synuclein Constructs Trap N-terminal Acetyltransferase NatB for Binding Mechanism Studies

This study creates a semi-synthetic inhibitor of NatB using coenzyme A and full-length alpha-synuclein, revealing structural and conformational changes upon binding.

Molecular mechanism of N-terminal acetylation by the ternary NatC complex

The paper reports the Cryo-EM structure of S. pombe NatC complex and identifies IP6 as a stabilizer, revealing substrate specificity overlaps with NatE.

Novel bisubstrate inhibitors for protein N-terminal acetyltransferase D

This study designs and characterizes potent bisubstrate inhibitors for NatD, showing high selectivity and revealing the enzyme's ordered Bi-Bi mechanism through crystal structures.

Identification and Characterization of a B-Raf Kinase Alpha Helix Critical for the Activity of MEK Kinase in MAPK Signaling

The paper identifies an alpha helix on B-Raf critical for its interaction with MEK and oncogenic activity, suggesting it as a potential drug target for melanoma treatment.

Molecular Basis for N-terminal Alpha-Synuclein Acetylation by Human NatB

The paper reports the cryo-EM structure of hNatB bound to a CoA-Syn conjugate and analyzes mutational effects on catalysis, revealing substrate-specific recognition mechanisms.

Structural and molecular determinants of CCS-mediated copper activation of MEK1/2

The paper reports the X-ray structure of Cu-MEK1, revealing Cu coordination and CCS-mediated Cu transfer, and identifies molecular mechanisms for Cu-stimulated MEK1 kinase activity.

Tyrosine phosphorylation of ACLY regulates lipid metabolism and oncogenesis in ALK positive Anaplastic Large Cell Lymphoma

This study identifies tyrosine phosphorylation of ACLY at Y682 as a regulatory mechanism linked to lipid metabolism and oncogenesis in ALK-positive ALCL.