Author

K. Shang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Assay:proteomics· 1

Frequent Co-Authors

C. Zhou· 2 shared J. Chen· 2 shared J. Sun· 2 shared X. Gao· 2 shared X. Meng· 2 shared X. Wu· 2 shared Y. Duan· 2 shared Y. Huang· 2 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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2 shared papersImmunology

C. Zhou

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Author profile →

2 papers

Recent·Most cited

Balancing activation and costimulation of CAR tunes signaling dynamics and enhances therapeutic potency

J. Sun, Y. Duan, J. Chen, X. Meng, L. Liu, K. Shang, X. Wu, Y. Wang, Z. Huang, H. Liu, Y. Huang, C. Zhou, X. Gao, Y. Wang, M. Sadelain

This study shows that modifying CAR activation motifs improves anti-tumor efficacy in solid tumors despite reduced in vitro cytotoxicity.

bioRxiv · Mar 1, 2022Immunology

Cas9-cleavage sequences in minimal plasmids enhance non-viral genome targeting of CARs in primary human T cells

R. Jing, P. Jiao, j. chen, X. Meng, X. Wu, Y. Duan, K. Shang, L. Qian, Y. Huang, J. Liu, T. Huang, J. Jin, W. Chen, X. Zeng, W. Yin, , J. Sun

This paper develops a non-viral method for efficient T cell genome editing using modified plasmids, achieving CAR-T cell functionality comparable to AAV-based methods.

bioRxiv · Dec 31, 2020Bioengineering