Author

K. Simons

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1 Pathology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:metabolomics· 3 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

C. Klose· 4 shared M. A. Surma· 3 shared J. Ferreira· 2 shared J. Sampaio· 2 shared N. Domingues· 2 shared O. V. Vieira· 2 shared R. Matthiesen· 2 shared W. Vaz· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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4 shared papersPathology

C. Klose

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Cholesteryl hemiazelate Identified in Cardiovascular Disease Patients Causes in vitro and in vivo Inflammation

N. Domingues, J. Gaifem, R. Matthiesen, D. Saraiva, L. Bento, A. Marques, I. Soares, J. Sampaio, C. Klose, M. Surma, M. Almeida, G. Mendes, P. Goncalves, J. Ferreira, R. Gouveia e Melo, , O. V. Vieira

The paper identifies cholesteryl hemiazelate (ChA) as an oxidized lipid that induces inflammation in vitro and in vivo, contributing to atherosclerosis.

bioRxiv · Feb 9, 2023 · PreprintPathology

Flexibility of a mammalian lipidome - insights from mouse lipidomics

M. A. Surma, M. J. Gerl, R. Herzog, J. Helppi, K. Simons, C. Klose

The paper investigates how diet, sex, and genotype affect the mouse lipidome across tissues, organs, and bodily fluids, providing baseline lipidomic data and insights into organ-specific flexibility.

bioRxiv · May 12, 2021Biochemistry

Cholesteryl Hemiazelate Induces Lysosome Dysfunction and Exocytosis in Macrophages

N. Domingues, R. D. A. Calado, P. Brito, R. Matthiesen, J. Ramalho, M. I. L. Soares, T. Pereira, L. Oliveira, J. Vicente, L. H. Wong, S. M. Cho, I. Simoes, J. Sampaio, C. Klose, M. A. Surma, , O. V. Vieira

This study identifies cholesteryl hemiazelate as a cause of lysosome dysfunction and exocytosis in macrophages, contributing to atherosclerosis.

bioRxiv · Jan 5, 2021 · PreprintCell Biology

Comprehensive and quantitative analysis of white and brown adipose tissue by shotgun lipidomics

M. Grzybek, A. Palladini, V. I. Alexaki, M. A. Surma, K. Simons, T. Chavakis, C. Klose, U. Coskun

This paper presents a validated shotgun lipidomics method for adipose tissue, revealing diet-related lipidomic differences in brown, gonadal, and inguinal subcutaneous fat from lean and obese mice.

bioRxiv · Nov 14, 2018 · PreprintPhysiology