M. Almeida

The effect of estradiol during the early stages of osteoclast differentiation is associated with the accumulation of phosphorylated p53 in mitochondria and the inhibition of mitochondrial metabolism.

This study investigates how estradiol affects mitochondrial metabolism and apoptosis in osteoclast progenitors during early differentiation, revealing p53 accumulation in mitochondria as a key mechanism.

Cholesteryl hemiazelate Identified in Cardiovascular Disease Patients Causes in vitro and in vivo Inflammation

The paper identifies cholesteryl hemiazelate (ChA) as an oxidized lipid that induces inflammation in vitro and in vivo, contributing to atherosclerosis.

In vitro modelling of oral microbial invasion in the human colon

This study develops an in vitro model to simulate oral microbial invasion of the human colon and finds that oral microorganisms preferentially colonize the mucosal compartment.

Establishment of physiologically relevant oxygen gradients in microfluidic organ chips

This paper establishes a method to create physiologically relevant oxygen gradients in a microfluidic intestine-on-a-chip model, supporting stable oxygen levels and intestinal barrier integrity.

Bacterial predation on T4 phages

The paper demonstrates that bacteria can consume T4 phages, leading to phage disappearance and bacterial growth in wastewater sludge.