Cancer BiologybioRxiv
Inducible lncRNA transgenic mice reveal continual role of HOTAIR in promoting breast cancer metastasis
Q. Ma, L. Yang, K. Tolentino…·H. Chang
This study uses a transgenic mouse model to show that sustained HOTAIR expression promotes breast cancer metastasis and that its removal reverses metastatic traits, indicating an erasable epigenetic memory.
DOI 10.7554/elife.79126