Author

I. Lai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Immunology· 2 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Assay:proteomics· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2

Frequent Co-Authors

C. Yee· 2 shared D. W. Felsher· 2 shared J. Park· 2 shared J. Wang· 2 shared K. Pan· 2 shared M. Chen· 2 shared S. Singh· 2 shared Y. Chiu· 2 shared

Activity by Year

2021-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersImmunology

C. Yee

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

An Investigation of the Effects of Nitrate vs. Ammonium on Plants Using Metabolic Modeling

I. Lai, C. Y. M. Cheung

This paper uses metabolic modeling to investigate how nitrate and ammonium affect plant metabolism, predicting tissue-specific changes and potential applications for improving crop yield.

bioRxiv · Oct 11, 2022 · PreprintPlant Biology

MYC Overexpression Drives Immune Evasion in Human Cancer that is Reversible Through Restoration of Pro-Inflammatory Macrophages

R. Dhanasekaran, A. S. Hansen, J. Park, I. Lai, N. Adeniji, S. Kuruvilla, A. Suresh, V. Swamy, D. W. Felsher

This paper shows that MYC overexpression in cancers suppresses immune surveillance by inhibiting pro-inflammatory macrophages, and this immune evasion can be reversed by combined PDL1 and CTLA4 blockade.

bioRxiv · May 13, 2022 · PreprintCancer Biology

Inducible lncRNA transgenic mice reveal continual role of HOTAIR in promoting breast cancer metastasis

Q. Ma, L. Yang, K. Tolentino, Y. Zhao, U. M. Lizenburger, Q. Shi, L. Zhu, M.-C. Tsai, J.-A. Chen, I. Lai, H. Zeng, L. Li, H. Chang

This study uses a transgenic mouse model to show that sustained HOTAIR expression promotes breast cancer metastasis and that its removal reverses metastatic traits, indicating an erasable epigenetic memory.

bioRxiv · Apr 21, 2022Cancer Biology

Bi-steric mTORC1-selective Inhibitors activate 4EBP1 reversing MYC-induced tumorigenesis and synergize with immunotherapy

W. D. Mahauad-Fernandez, Y. C. Yang, I. Lai, J. Park, L. Yao, J. W. Evans, G. L. Burnett, A. Gill, J. A. M. Smith, M. Singh, D. W. Felsher

This study identifies bi-steric mTORC1-selective inhibitors that reactivate 4EBP1, suppress MYC-driven tumors, and enhance immunotherapy in multiple cancer models.

bioRxiv · Feb 4, 2022 · PreprintCancer Biology

Immunogenic SARS-CoV2 Epitopes Defined by Mass Spectrometry

K. Pan, Y. Chiu, E. Huang, M. Chen, J. Wang, I. Lai, S. Singh, R. Shaw, M. J. MacCoss, C. Yee

This study identifies novel SARS-CoV-2 epitopes using mass spectrometry and validates their immunogenicity by T cell recognition.

bioRxiv · Jul 20, 2021 · PreprintImmunology

In Silico Defined SARS-CoV2 Epitopes May Not Predict Immunogenicity to COVID19

K. Pan, Y. Chiu, M. Chen, J. Wang, I. Lai, S. Singh, R. M. Shaw, C. Yee

This study shows that in silico predicted SARS-CoV-2 epitopes do not reliably elicit T cell responses against naturally presented epitopes.

bioRxiv · Jul 8, 2021 · PreprintImmunology