K. W. Moremen

This paper uses sulfotransferase substrate specificities to enzymatically synthesize keratan sulfate oligosaccharides and investigates their binding properties with lectins and viral proteins.

The study shows the PAN domain in G-type lectin receptor-like kinases suppresses JA/ET defense pathways in plants by promoting receptor degradation.

The paper investigates site-specific rates of glycan processing in vitro and finds that local structural factors influence enzymatic modification efficiency and microheterogeneity.

This study shows matriglycan can independently bind Laminin, viral proteins, and antibodies, and block viral infection, suggesting it acts as a tunable receptor.

The paper demonstrates that glycan remodeling of erythrocytes enables antigenic characterization of recent A/H3N2 influenza viruses that lack agglutination ability.

The paper shows that modulating Siglec-7 signaling via high-affinity cis-ligands on NK cells can suppress or enhance NK cytotoxicity depending on ligand concentration.

This study modifies NK cells with CD22 and selectin glycan ligands to enhance B-cell lymphoma targeting and trafficking, achieving effective tumor suppression in a xenograft model.

The paper characterizes AtXOAT1, a plant xylan O-acetyltransferase, revealing its structural and mechanistic details for xylan acetylation.

This study develops a live cell assay using hFUT1 to profile α1-2-fucosides' role in enhancing influenza A virus infection.

The paper develops a single-step fluorescent glycan labeling method to image sialylation and fucosylation in live zebrafish embryos, revealing their roles in hematopoiesis.