Author

L. Wells

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 6 Cell Biology· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 7 Assay:proteomics· 5 Approach:statistical model· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Approach:biophysical modeling· 1

Frequent Co-Authors

J. L. Praissman· 3 shared M. O. Sheikh· 3 shared P. Zhao· 3 shared C. Iorio· 2 shared K. W. Moremen· 2 shared M. A. Brindley· 2 shared M. Tiemeyer· 2 shared R. Bridger· 2 shared

Activity by Year

2019-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersBiochemistry

J. L. Praissman

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Author profile →

10 papers

Recent·Most cited

Sequential in vitro enzymatic N-glycoprotein modification reveals site-specific rates of glycoenzyme processing

T. M. Adams, P. Zhao, D. Chapla, K. W. Moremen, L. Wells

The paper investigates site-specific rates of glycan processing in vitro and finds that local structural factors influence enzymatic modification efficiency and microheterogeneity.

bioRxiv · Jul 27, 2022Biochemistry

Role of the G-Protein Coupled Receptor 3-Salt Inducible Kinase 2 Pathway in Human β CellProliferation

C. Iorio, J. L. Rourke, L. Wells, J.-I. Sakamaki, E. Moon, Q. Hu, T. Kin, R. Screaton

This study identifies the GPR3-SIK2 pathway as a regulator of human β cell proliferation, showing that GPR3 silencing activates SIK2 to drive cell cycle entry and increase β cell mass.

bioRxiv · May 31, 2021Cell Biology

Cell Surface Glycan Engineering Reveals that Matriglycan Alone can Recapitulate Dystroglycan Binding and Function

M. O. Sheikh, C. J. Capicciotti, L. Liu, J. L. Praissman, D. G. Mead, M. A. Brindley, T. Willer, K. P. Campbell, K. W. Moremen, L. Wells, G.-J. Boons

This study shows matriglycan can independently bind Laminin, viral proteins, and antibodies, and block viral infection, suggesting it acts as a tunable receptor.

bioRxiv · May 10, 2021Biochemistry

ROMO1 and Mitochondrial Complex II/SDH are Required for Spare Respiratory Capacity and Glucose Homeostasis in Mice

L. Wells, Q. Yang, C. Iorio, M. Peragerasingam, Z. Campbell, A. C.-H. Ng, C. Reeks, S.-P. Yee, R. A. Screaton

This study shows that ROMO1 is essential for mouse development and maintains spare respiratory capacity and glucose homeostasis in pancreatic beta cells.

bioRxiv · Apr 28, 2021Cell Biology

Separation and identification of permethylated glycan isomers by reversed phase nanoLC-NSI-MSn

S. Kurz, M. O. Sheikh, S. Lu, L. Wells, M. Tiemeyer

This paper develops an optimized LC-MSn workflow for separating and identifying permethylated glycan isomers without requiring glycan standards or high-resolution mass spectrometers.

bioRxiv · Aug 4, 2020Biochemistry

Generation of an Unbiased Interactome for the Tetratricopeptide Repeat Domain of O-GlcNAc Transferase Indicates a Role for the Enzyme in Intellectual Disability

H. M. Stephen, J. L. Praissman, L. Wells

This study identifies the interactome of the OGT TPR domain using BioID, revealing novel interactions linked to intellectual disability and other diseases.

bioRxiv · Jul 30, 2020Biochemistry

Virus-Receptor Interactions of Glycosylated SARS-CoV-2 Spike and Human ACE2 Receptor

P. Zhao, J. L. Praissman, O. C. Grant, Y. Cai, T. Xiao, K. E. Rosenbalm, K. Aoki, B. P. Kellman, R. Bridger, D. H. Barouch, M. A. Brindley, N. E. Lewis, M. Tiemeyer, B. Chen, R. J. Woods, L. Wells

The paper characterizes glycosylation of SARS-CoV-2 Spike and ACE2 using glycomics and simulations to understand their interactions and guide immunogen design.

bioRxiv · Jun 25, 2020Biochemistry

A glycogenin homolog controls Toxoplasma gondii growth via glycosylation of an E3 ubiquitin ligase

M. Mandalasi, H. W. Kim, D. Thieker, M. O. Sheikh, E. Gas-Pascual, K. Rahman, P. Zhao, N. G. Daniel, H. van der Wel, T. H. Ichikawa, J. N. Glushka, L. Wells, R. J. Woods, Z. A. Wood, C. M. West

This study identifies Gat1, a glycogenin homolog, as essential for adding the terminal sugar to Skp1 in Toxoplasma gondii, which is critical for parasite growth.

bioRxiv · Feb 2, 2020 · PreprintMicrobiology

Identification of a Novel Base J Binding Protein Complex Involved in RNA Polymerase II Transcription Termination in Trypanosomes

R. Sabatini, R. Kieft, Y. Zhang, A. Marand, J. Moran, R. Bridger, L. Wells, R. J. Schmitz

This study identifies a novel J-binding protein complex involved in RNA Polymerase II transcription termination in trypanosomes, linking base J modification to termination regulation.

bioRxiv · Aug 30, 2019Biochemistry

The human UDP-galactose 4’-epimerase (GALE) is required for cell surface glycome structure and function

A. Broussard, A. Florwick, C. Desbiens, N. Nischan, C. Robertson, Z. Guan, J. J. Kohler, L. Wells, M. Boyce

This study shows that GALE regulates nucleotide-sugar levels, affecting glycan structures and cell signaling, particularly in death receptor pathways.

bioRxiv · May 23, 2019Cell Biology