Author

K.-P. Wu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:bacteria (other)· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Organism:E. coli· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. K. N. Chan· 1 shared B. Canard· 1 shared B. Ma· 1 shared B. Selisko· 1 shared C. Chen· 1 shared C. Eydoux· 1 shared C.-e. Chang· 1 shared D. S. C. Hui· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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1 shared paperMicrobiology

A. K. N. Chan

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Author profile →

4 papers

Recent·Most cited

What Strengthens Protein-Protein Interactions: Analysis and Applications of Residue Correlation Networks

T. I. Hung, Y.-J. Hsieh, W.-L. Lu, K.-P. Wu, C.-e. Chang

The paper identifies critical residues in protein-protein interactions through residue correlation networks and demonstrates a method to design high-affinity protein binders with improved selectivity and potency.

bioRxiv · Mar 15, 2023Biophysics

Cryo-EM reveals the structure and dynamics of a 723-residue malate synthase G

M.-R. Ho, Y.-M. Wu, Y.-C. Lu, T.-P. Ko, K.-P. Wu

The paper presents a 2.9-Å cryo-EM structure of malate synthase G from E. coli, showing it matches crystallographic and NMR structures and reveals conformational dynamics.

bioRxiv · Aug 19, 2022Biophysics

Structural basis of transcriptional activation by the OmpR/PhoB-family response regulator PmrA

Y.-C. Lou, H.-Y. Huang, H.-H. Yeh, W.-H. Chiang, C. Chen, K.-P. Wu

The paper reports a cryo-EM structure of a PmrA-dependent transcription activation complex and shows how PmrA interacts with DNA and RNA polymerase to activate gene transcription.

bioRxiv · Jul 20, 2022 · PreprintBiophysics

Simeprevir suppresses SARS-CoV-2 replication and synergizes with remdesivir

H. S. Lo, K. P. Y. Hui, H.-M. Lai, K. S. Khan, S. Kaur, J. Huang, Z. Li, A. K. N. Chan, H. H.-Y. Cheung, K. C. Ng, J. C. W. Ho, Y. W. Chen, B. Ma, P. M.-H. Cheung, D. Shin, , W.-L. Ng

The paper identifies simeprevir as a potent inhibitor of SARS-CoV-2 replication that synergizes with remdesivir in vitro.

ACS Central Science · Apr 15, 2021Peer-reviewedMicrobiology