Author

M. Garcia-Macia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 3 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:differential expression· 1

Frequent Co-Authors

A. Santos-Ledo· 2 shared J. P. Bolanos· 2 shared A. A. Rahim· 1 shared A. Almeida· 1 shared A. Coto-Montes· 1 shared A. Dowsey· 1 shared A. E. Burrows· 1 shared A. Philips· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCell Biology

A. Santos-Ledo

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Author profile →

5 papers

Recent·Most cited

Weak neuronal glycolysis sustains cognition and organismal fitness

D. Jimenez-Blasco, J. Agulla, R. Lapresa, M. Garcia-Macia, V. Bobo-Jimenez, D. Garcia-Rodriguez, I. Manjarres-Raza, E. Fernandez, Y. Jeanson, S. Khoury, J.-C. Portais, D. Padro, P. Ramos-Cabrer, P. Carmeliet, A. Almeida, J. P. Bolanos

This study shows that weak neuronal glycolysis supports cognition and organismal fitness by preventing mitochondrial redox stress and maintaining autophagy.

bioRxiv · Sep 2, 2023Cell Biology

CLN7 mutation causes aberrant redistribution of protein isoforms and contributes to Batten disease pathobiology

A. Sharaireh, M. Guevara Ferrer, S. Herranz-Martin, M. Garcia-Macia, A. Philips, A. Tierney, M. P. Hughes, O. Coombe-Tennant, H. Nelvagel, A. E. Burrows, S. Fielding, L. M. FitzPatrick, C. D. Thornton, S. Storch, S. E. Mole, , T. R. McKay

This study shows CLN7 mutations cause nuclear and endolysosomal protein distribution defects in Batten disease, leading to apoptosis and neuroinflammation, suggesting combinatorial therapies may be needed.

bioRxiv · Apr 21, 2022 · PreprintCell Biology

Inhibiting the prostaglandin transporter PGT induces non-canonical thermogenesis at thermoneutrality

V. J. Pai, R. Lu, L. Wu, M. Garcia-Macia, W. R. Koba, Y. Chi, R. Singh, G. J. Schwartz, V. L. Schuster

Inhibiting the prostaglandin transporter PGT reduces body fat and induces UCP1-independent thermogenesis in mice on a high-fat diet.

bioRxiv · Nov 9, 2019 · PreprintPhysiology

mTORC1-Plin3 pathway is essential to activate lipophagy and protects against hepatosteatosis.

M. Garcia-Macia, A. Santos-Ledo, J. Leslie, H. Paish, A. Watson, L. Borthwick, J. Mann, F. Oakley, V. I. Korolchuk, D. A. Mann

This study identifies the mTORC1-Plin3 pathway as essential for lipophagy, which protects against hepatosteatosis by promoting lipid droplet degradation.

bioRxiv · Oct 21, 2019Cell Biology

Selective autophagy, lipophagy and mitophagy, in the Harderian gland along the estrous cycle: a potential retrieval effect of melatonin

M. Garcia-Macia, A. Santos-Ledo, B. Caballero, A. Rubio-Gonzalez, B. de Luxan-Delgado, Y. Potes, S. Rodriguez-gonzalez, J. A. Boga, A. Coto-Montes

The paper investigates autophagy types in the Harderian gland during the estrous cycle, finding melatonin modulates autophagy via Nrf2 and reduces pro-inflammatory mediators.

bioRxiv · May 29, 2019Cell Biology