S. Parthasarathy

Mutation of a highly conserved isoleucine residue in loop 2 of several ????-coronavirus macrodomains indicates that enhanced ADP-ribose binding is detrimental to infection

This study shows that mutating a conserved isoleucine in the macrodomain of MERS-CoV and SARS-CoV-2 enhances ADP-ribose binding but reduces viral replication and pathogenesis.

PARP12 is required to repress the replication of a Mac1 mutant coronavirus in a cell and tissue specific manner

This paper shows PARP12 inhibits replication of a Mac1 mutant coronavirus in some cell and tissue types but not all, suggesting other PARPs also contribute to antiviral defense.

SARS-CoV-2 Mac1 is required for IFN antagonism and efficient virus replication in mice

This study shows that SARS-CoV-2 Mac1 is essential for pathogenesis but not replication, as Mac1-deleted virus replicates normally but induces higher IFN responses and reduced disease in mice.

T-cell cellular stress and reticulocyte signatures, but not loss of naive T lymphocytes, characterize severe COVID-19 in older adults

The paper identifies T-cell stress and reticulocyte signatures as markers of severe COVID-19 in older adults, while showing naive T-cell decline is age-related, not disease-specific.

Toroidal displacement of Klebsiella pneumoniae by Pseudomonas aeruginosa is a unique mechanism to avoid competition for iron

This study identifies a unique mechanism where Pseudomonas aeruginosa displaces Klebsiella pneumoniae using rhamnolipid biosurfactant under iron-limited conditions to reduce competition for iron.

Oxytocin receptor is not required for social attachment in prairie voles

This study shows that oxytocin receptor signaling is not required for social attachment, parturition, or parental behavior in prairie voles.