L. Mueller

MMR vaccination induces a trained immunity program characterized by functional and metabolic reprogramming of γδ T cells

MMR vaccination induces functional and metabolic reprogramming of γδ T cells, enhancing their activation and cytokine production.

A Vaccinia-based system for directed evolution of GPCRs in mammalian cells

This paper develops a Vaccinia-based system to evolve GPCRs in mammalian cells, improving stability and expression, and demonstrating functional receptor properties.

The Cilialyzer - a freely available open-source software for a standardised identification of impaired mucociliary activity facilitating the diagnostic testing for PCD

The paper introduces Cilialyzer, an open-source software for analyzing mucociliary activity in PCD diagnostics, providing quantitative metrics like ciliary beating frequency and transport speed.

Design of D-amino acids SARS-CoV-2 Main protease inhibitors using the cationic peptide from rattlesnake venom as a scaffold

The paper designs D-amino acid-based inhibitors of SARS-CoV-2 3CLpro using a rattlesnake venom peptide scaffold, showing in vitro and in vivo antiviral activity.

A Pan-respiratory Antiviral Chemotype Targeting a Host Multiprotein Complex

The paper identifies a novel antiviral chemotype effective against multiple respiratory viruses by targeting a host multi-protein complex involved in viral lifecycle and innate immunity.

SARS-CoV-2 targets cortical neurons of 3D human brain organoids and shows neurodegeneration-like effects

This study shows SARS-CoV-2 infects cortical neurons in 3D human brain organoids, causing neurodegeneration-like effects such as Tau mislocalization and neuronal death.

Network Topology Dynamics of Circulating Biomarkers and Cognitive Performance in Older Cytomegalovirus-seropositive or -seronegative Men and Women

The paper analyzes network topology dynamics of 22 biomarkers and 11 cognitive measures in older CMV-seropositive and -seronegative individuals, finding differences in network properties by CMV status and sex.