L. Du

Elucidating Electronic Structure Variations in Nucleic Acid-Protein Complexes Involved in Transcription Regulation Using a Tight-Binding Approach

This paper introduces a tight-binding method to model electronic structure properties of transcription factor-DNA complexes, using random forest regression to generate parameters from ab-initio calculations.

Thymidine Phosphorylase Promotes the Formation of Abdominal Aortic Aneurysm in Mice Fed a Western Diet

This study shows that TYMP promotes abdominal aortic aneurysm (AAA) in mice fed a Western diet by enhancing inflammation, thrombosis, and MMP2 activation while inhibiting vascular smooth muscle cell function.

Conversion of monoclonal IgG to dimeric and secretory IgA restores neutralizing ability and prevents infection of Omicron lineages

Engineered dimeric and secretory IgA1 neutralized Omicron variants with higher potency than parental IgG.

GTPase-activating protein ARAP1 regulates circular dorsal ruffles as a nutrient uptake mechanism in the Hep3B hepatocellular carcinoma cell line

This study shows that ARAP1 regulates circular dorsal ruffles in Hep3B cells, and its deletion reduces malignant potential, suggesting CDRs contribute to cancer development through nutrient uptake.

Modification of social cheating facilitates the stabilization and chronic infection of polymorphic Pseudomonas aeruginosa population

The paper shows that evolution in Pseudomonas aeruginosa populations selects for cheater mutants that modify social cooperation to stabilize chronic infections and reduce host immune response.

Conventional dendritic cells 2, the targeted antigen-presenting-cell, induces enhanced type 1 immune responses in mice immunized with CVC1302 in oil formulation

This study shows that CVC1302 in oil formulation enhances Th1 immune responses by targeting antigen and inflammatory monocytes to lymph node inter-follicular regions and promoting IL-12 production by cDC2.

Cardiac performance and heat shock response variation related to shell colour morphs in the mudflat snail Batillaria attramentaria

This study compares thermal stress responses and transcriptomic profiles of different shell colour morphs in the snail Batillaria attramentaria, finding that dark morphs exhibit preparative defense strategies and higher cardiac thermal tolerance.

Understanding the Spin Crossover Dynamical Effects of the Dioxygen Binding and Activation on HOD Enzyme

This study investigates the spin crossover dynamics of dioxygen activation in HOD enzyme using Born-Oppenheimer and non-adiabatic surface hopping dynamics, showing non-adiabatic effects are essential for O2 activation.

Human Galectin-9 Potently Enhances SARS-CoV-2 Replication and Inflammation in Airway Epithelial Cells

This study shows that galectin-9 enhances SARS-CoV-2 replication and inflammation in airway epithelial cells by promoting viral entry and activating pro-inflammatory pathways.

Comprehensive dissection of immune microenvironment in the progression of early gastric cancer at spatial and single-cell resolution

This study uses spatial transcriptomics and single-cell RNA-seq to analyze immune microenvironment changes in gastric cancer progression, identifying immune cell dysregulation and key signaling pathways.

Mutual Regulation between PFKP and VEGF Promotes Glioblastoma Tumor Growth

This study identifies a mutual regulatory loop between PFKP and VEGF that promotes glioblastoma growth through AKT-mediated signaling and glycolytic enhancement.

Immunity to SARS-CoV-2 up to 15 months after infection

This study tracks SARS-CoV-2 immunity in patients up to 15 months post-infection, showing sustained antibody and memory B/T cell responses but reduced neutralization against variants.

The creation of functioning gastrojejunostomy following magnetic compression

This study evaluates methods for creating gastrojejunostomy using magnetic compression and pyloric ligation in rabbits, finding that pyloric ligation provides better long-term patency than paclitaxel-loaded magnets.

Resident Cardiac Macrophages Mediate Adaptive Myocardial Remodeling

This study identifies CCR2- resident cardiac macrophages as critical for adaptive myocardial remodeling in heart failure, showing their role in ventricular remodeling and coronary angiogenesis.

A Pan-respiratory Antiviral Chemotype Targeting a Host Multiprotein Complex

The paper identifies a novel antiviral chemotype effective against multiple respiratory viruses by targeting a host multi-protein complex involved in viral lifecycle and innate immunity.

Description, taxonomy, and comparative genomics of a novel Thermoleptolyngbya strain isolated from hot springs of Ganzi, Sichuan China.

The paper describes a novel Thermoleptolyngbya strain, identifies it as a new species using phylogenetic and genomic analyses, and explores its genomic features and adaptive capabilities.

Amphipathic Bax core dimer forms part of apoptotic pore wall in the mitochondrial membrane

This study determines the structure of the Bax core dimer and shows it forms part of the mitochondrial pore wall during apoptosis.

Data-informed discovery of hydrolytic nanozymes

This paper develops data-informed strategies to design hydrolytic nanozymes with enhanced catalytic activity and broad substrate specificity.

Scavenger receptor A1 participates in the phagocytosis of Leptospira interrogans and leads to subsequent high inflammatory responses and bacterial dissemination in leptospirosis

This study shows that SR-A1 facilitates Leptospira phagocytosis by macrophages but also promotes bacterial dissemination and inflammation, worsening leptospirosis in mice.

The Development of a Novel Nanobody Therapeutic for SARS-CoV-2

This paper develops a potent, low-cost nanobody therapeutic, Nanosota-1C-Fc, that effectively blocks SARS-CoV-2 infection in vitro and in vivo with high affinity and stability.

Persistence of SARS-CoV-2 specific B- and T-cell responses in convalescent COVID-19 patients 6-8 months after the infection

This study tracks SARS-CoV-2 specific B- and T-cell responses in convalescent patients 6-8 months post-infection, finding sustained memory cell responses despite declining antibody levels.

The Biogeography of Fungal Communities Across Different Chinese Wine-producing Regions Associated with Environmental Factors and Spontaneous Fermentation Performance

This study analyzes fungal communities in Chinese Marselan wine fermentation across regions, finding that environmental factors significantly influence fungal composition and fermentation performance.

A key linear epitope for a potent neutralizing antibody to SARS-CoV-2 S-RBD

This study identifies a linear epitope on SARS-CoV-2 S-RBD recognized by a potent neutralizing antibody and shows its potential for vaccine design.

A rapid and efficient screening system for neutralizing antibodies and its application for the discovery of potent neutralizing antibodies to SARS-CoV-2 S-RBD

This paper introduces a rapid screening system to identify potent neutralizing antibodies against SARS-CoV-2 and demonstrates its effectiveness in discovering high-potency antibodies.

Biomechanical Characterization of SARS-CoV-2 Spike RBD and Human ACE2 Protein-Protein Interaction

This study quantifies the biophysical differences in SARS-CoV-2 and SARS-CoV-1 RBD-ACE2 interactions using single-molecule force spectroscopy and SMD simulations, revealing a key N-glycan interaction in SARS-CoV-2 that enhances binding affinity.

An enormous Paris polyphylla genome sheds light on genome size evolution and polyphyllin biogenesis

This study reports the largest sequenced plant genome, Paris polyphylla var. yunnanensis, and identifies genes involved in polyphyllin biosynthesis.

Yeast-Expressed SARS-CoV Recombinant Receptor-Binding Domain (RBD219-N1) Formulated with Aluminum Hydroxide Induces Protective Immunity and Reduces Immune Enhancement

This paper develops a SARS-CoV subunit vaccine using yeast-expressed RBD219-N1 with Alhydrogel® and shows it provides full protection against SARS-CoV challenge in mice.

Inhibition of SARS-CoV-2 infection (previously 2019-nCoV) by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion

This paper identifies EK1C4, a potent fusion inhibitor against SARS-CoV-2 and other coronaviruses, showing high efficacy in vitro and in vivo.

Essentiality of CREBBP in EP300 truncated B-cell lymphoma revealed by genome-wide CRISPR-Cas9 screen

The paper identifies CREBBP dependency in a DLBCL cell line with EP300 truncation using CRISPR-Cas9 screens and genomic data, suggesting therapeutic targets for heterogeneous cancers.

Arginine-GlcNAcylation of death domain and NleB/SseK proteins is crucial for bacteria pathogenesis by regulating host cell death

This study identifies arginine-GlcNAcylation as a mechanism by which bacterial effectors NleB and SseKs modulate host death receptor signaling to promote pathogenesis.