ImmunologybioRxivPreprint
Tumor microenvironments impair T cell receptor affinity and function
Z. Yuan, M. J. O'Melia, K. Li…·C. Zhu
This study shows that CD8+ T cells in the tumor microenvironment have reduced TCR-pMHC affinity and function, impairing their anti-tumor activity.
DOI 10.1101/2022.09.11.507496