L. Schaedel

Multiple clustered centrosomes in antigen-presenting cells foster T cell activation without MTOC polarization

This study shows that multiple clustered centrosomes in antigen-presenting cells enhance T cell activation by positioning near the cell center, unlike T cells where centrosomes polarize toward the immune synapse.

Global alignment and local curvature of microtubules in mouse fibroblasts are robust against perturbations of vimentin and actin

This study examines how actin and vimentin affect microtubule structure and curvature in mouse fibroblasts, finding that microtubule orientation and bending are largely independent of these cytoskeletal components.

Vimentin Intermediate Filaments Stabilize Dynamic Microtubules by Direct Interactions

This study shows vimentin intermediate filaments stabilize microtubules by direct interactions, providing insights into cytoskeletal dynamics and a method to estimate tubulin dimer binding energy.

CLASP mediates microtubule repair by promoting tubulin incorporation into damaged lattices

This study shows CLASP2 promotes microtubule lattice repair by facilitating tubulin incorporation into damaged sites and stabilizing partial protofilaments.

Self-repair protects microtubules from their destruction by molecular motors

The paper investigates how molecular motors affect microtubule stability and discovers a self-repair mechanism that counteracts motor-induced damage.

Lattice defects induce microtubule self-renewal

This study shows that microtubules can exchange dimers along their shaft, requiring lattice defects, enabling self-renewal and potential regulation of signaling and structural changes.