Author

A. Tong

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Cancer Biology· 2 Bioengineering· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Approach:deep learning· 2 Assay:DNA methylation· 2 Organism:human· 2 Assay:proteomics· 2 Organism:bacteria (other)· 1

Frequent Co-Authors

S. Krishnaswamy· 2 shared A. Alvarez Quilon· 1 shared A. Bhagwat· 1 shared A. Martin· 1 shared A. Naik· 1 shared A. Venkat· 1 shared B. Perez San Juan· 1 shared C. Bustamante· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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2 shared papersCancer Biology

S. Krishnaswamy

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Revealing dynamic temporal trajectories and underlying regulatory networks with Cflows

X. Sun, S. Gupta, A. Tong, M. Kuchroo, D. Bhaskar, C. Liu, A. Venkat, B. Perez San Juan, L. Rangel, V. Rodriguez, J. G. Lock, C. Chaffer, S. Krishnaswamy

Cflows infers continuous cell state transitions and gene regulatory networks from static scRNA-seq data, revealing ESRRA as a key driver of tumor formation.

bioRxiv · Mar 28, 2023 · PreprintCancer Biology

Trellis Single-Cell Screening Reveals Stromal Regulation of Patient-Derived Organoid Drug Responses

M. Ramos Zapatero, A. Tong, J. Sufi, P. Vlckova, F. Cardoso Rodriguez, C. Nattress, X. Qin, D. Hochhauser, S. Krishnaswamy, C. J. Tape

The paper develops Trellis, a method to analyze single-cell drug responses in PDOs and CAFs, revealing patient-specific apoptosis and CAF-mediated chemoprotection via YAP signaling.

bioRxiv · Oct 19, 2022 · PreprintCancer Biology

FAM72A antagonizes UNG2 to promote mutagenic uracil repair during antibody maturation

Y. Feng, C. Li, J. Stewart, P. Barbulescu, N. Seija Desivo, A. Alvarez Quilon, R. Pezo, M. Perera, K. Chan, A. Tong, R. Mohamad-Ramshan, M. Berru, D. Nakib, G. Li, G. Kardar, , A. Martin

This study identifies FAM72A as a regulator of mutagenic uracil repair during antibody maturation by antagonizing UNG2 activity.

bioRxiv · Dec 23, 2020Immunology

A DNA translocase operates by cycling between planarand lock-washer structures

J. P. Castillo, A. Tong, S. Tafoya, P. J. Jardine, C. Bustamante

The paper studies a DNA translocase that adapts its translocation mechanism to different substrates by altering its structural conformation.

bioRxiv · May 22, 2020 · PreprintBiophysics

An Automated Addressable Microfluidics Device for Minimally-Invasive Manipulation of Cells and Fluids within Living Cultures

A. Tong, L. Q. Pham, V. Shah, A. Naik, P. Abatemarco, R. Voronov

This paper introduces an automated microfluidics device for minimally invasive cell and fluid manipulation in living cultures, enabling better tissue engineering and monitoring.

ACS Biomaterials Science & Engineering · Feb 12, 2020Peer-reviewedBioengineering

Direct Binding of Phosphatidylglycerol at Specific Sites Modulates Desensitization of a Pentameric Ligand-Gated Ion Channel

A. Tong, J. T. Petroff, F.-F. Hsu, P. A. Schmidpeter, C. M. Nimigean, L. Sharp, G. Brannigan, W. W. Cheng

The paper shows that phosphatidylglycerol binds to and stabilizes the pentameric ligand-gated ion channel ELIC, reducing desensitization.

bioRxiv · Aug 7, 2019Biophysics