C. Guy

Human coronavirus 229E infection inactivates pyroptosis executioner gasdermin D but ultimately leads to lytic cell death partly mediated by gasdermin E

This study shows HCoV-229E Mpro inactivates GSDMD to block pyroptosis but promotes lytic cell death, partially via GSDME and caspases-3/-8.

Tetrameric UvrD helicase is located at the E. coli replisome due to frequent replication blocks

The paper shows UvrD forms tetramers and associates with replication forks due to frequent nucleoprotein blocks, distinct from Rep's recruitment mechanism.

Adaptation to host cell environment during experimental evolution of Zika virus

This study identifies genetic adaptations in Zika virus during experimental evolution in host cells, revealing increased infectivity and resistance to TLR3-induced restriction.

The inflammasome components NLRP3 and ASC act in concert with IRGM to rearrange the Golgi during viral infections

The paper shows NLRP3 and ASC work with IRGM to rearrange the Golgi during viral infections like HCV and ZIKV.

Subtractive Interaction Proteomics Reveal a Network of Signaling Pathways Activated by an Oncogenic Transcription Factor in Acute Myeloid Leukemia

This study uses subtractive interaction proteomics to identify signaling pathways activated by the t(6;9)-DEK/CAN oncogene in AML, revealing potential therapeutic targets.

Frequent Monitoring of C-peptide Levels in Newly Diagnosed Type 1 Subjects Using Dried Blood Spots Collected at Home

This study evaluates a method for frequent C-peptide monitoring at home using dried blood spots in newly diagnosed type 1 diabetes patients, showing strong correlation with plasma levels and potential for tracking beta-cell function changes.