Author

A. Kohl

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 11 Ecology· 1 Evolutionary Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 10 Approach:experimental assay· 9 Approach:statistical model· 5 Research Focus:drug response / drug discovery· 4 Organism:human· 4 Organism:Arabidopsis· 3 Organism:virus· 2 Assay:whole-genome sequencing· 2

Frequent Co-Authors

A. H. Patel· 3 shared A. M. Szemiel· 3 shared F. Almire· 3 shared A. da Silva Filipe· 2 shared E. C. Thomson· 2 shared E. Pondeville· 2 shared M. E. Stewart· 2 shared M. McFarlane· 2 shared

Activity by Year

2019-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersMicrobiology

A. H. Patel

Mutual co-authors in cluster

Author profile →

14 papers

Recent·Most cited

Genetic diversity of Toscana virus glycoproteins affects the kinetics of virus entry and the infectivity of newly produced virions

A. Thiesson, M.-P. Confort, S. Desloire, A. Kohl, F. Arnaud, M. Ratinier

This study investigates how genetic diversity in Toscana virus glycoproteins affects viral entry kinetics and infectivity, showing differences between two genetic lineages.

bioRxiv · Jul 22, 2024Microbiology

The PAZ domain of Aedes aegypti Dicer 2 is critical for accurate and high-fidelity size determination of virus-derived small interfering RNAs.

M. Reuter, R. H. Parry, M. McDonald, R. J. Gestuveo, R. Arif, A. A. Khromykh, B. Brennan, M. Varjak, A. Castello, L. Redecke, E. Schnettler, A. Kohl

This study identifies the PAZ domain's role in ensuring accurate 21 nt vsiRNA production by Dcr2 in Aedes aegypti, critical for antiviral responses against Semliki Forest virus.

bioRxiv · Jun 20, 2024 · PreprintMicrobiology

NSm is a critical determinant for bunyavirus transmission between vertebrate and arthropod hosts

S. Terhzaz, D. Kerrigan, F. Almire, A. M. Szemiel, M. Palmarini, A. Kohl, X. Shi, E. Pondeville

This study identifies NSm as a critical protein for bunyavirus transmission between vertebrate and arthropod hosts, showing its necessity for midgut infection and spread.

bioRxiv · Apr 17, 2024 · PreprintMicrobiology

The replication properties of a contemporary Zika virus from West Africa depends on NS1/NS4B proteins

D. Machmouchi, M.-P. Courageot, C. El-Kalamouni, A. Kohl, P. Despres

This study compares replication properties of a West African ZIKV strain with an African strain, identifying NS1/NS4B proteins as key factors in replication and stress granule suppression.

bioRxiv · Mar 14, 2024 · PreprintMicrobiology

Validation of an engineered Zika virus-like particle vaccine candidate in a mosquito-mouse transmission model

M. V. Mancini, R. Tandavanitj, T. H. Ant, S. M. Murdochy, D. D. Gingell, C. Setthapramote, P. Natsrita, A. Kohl, S. P. Sinkins, A. H. Patel, G. De Lorenzo

This study validates a ZIKV vaccine candidate by testing its efficacy in a mosquito-mouse transmission model, showing protection against disease and reduced viral transmission.

bioRxiv · Aug 8, 2022 · PreprintMicrobiology

A human and rhesus macaque interferon-stimulated gene screen reveals ARHGEF3/XPLN as an antiviral gene against hepatitis C virus and other flaviviruses

C. Bamford, E. Aranday-Cortes, R. Sanchez-Velazquez, C. Mullan, A. Kohl, A. H. Patel, S. J. Wilson, J. McLauchlan

This study identifies ARHGEF3/XPLN as an antiviral gene that inhibits HCV and flavivirus replication in both humans and rhesus macaques through a genome-wide screen.

bioRxiv · May 12, 2022 · PreprintMicrobiology

COVID-19: A need for new rather than repurposed antiviral drugs.

D. Kovacs, C. Davis, P. Cannon, M. McFarlane, S. M. Rainey, R. Pinto, M. E. Stewart, A. M. Szemiel, A. Taggart, A. Kohl, F. Marra, E. C. Thomson, J. T. Scott

This paper reviews 29 FDA-approved antiviral compounds for COVID-19 treatment, finds limited clinical efficacy of repurposed drugs, and highlights the need for novel antivirals.

bioRxiv · Mar 25, 2021 · PreprintMicrobiology

Inhibitors of the Small Membrane (M) Protein Viroporin Prevent Zika Virus Infection

E. Brown, G. Swinscoe, D. Lefteri, R. Singh, A. Moran, R. Thompson, D. Maskell, H. Beaumont, M. J. Bentham, C. Donald, A. Kohl, A. Macdonald, N. Ranson, R. Foster, C. S. McKimmie, , S. C. Griffin

This study identifies the ZIKV M protein as a therapeutic target, showing that inhibitors like rimantadine block viral infection in vitro and in vivo by targeting M-formed channels.

bioRxiv · Mar 11, 2021Microbiology

In vitro evolution of Remdesivir resistance reveals genome plasticity of SARS-CoV-2

A. M. Szemiel, A. Merits, R. J. Orton, O. MacLean, A. Wickenhagen, G. Lieber, R. M. Pinto, M. L. Turnbull, S. Wang, D. Mair, A. da Silva Filipe, B. J. Willett, S. J. Wilson, A. H. Patel, E. C. Thomson, , M. E. Stewart

This study shows that in vitro evolution of SARS-CoV-2 under remdesivir selects for resistant mutations, but these mutations do not spread widely in global variants.

bioRxiv · Feb 1, 2021Microbiology

Sugar feeding enhances gut immunity and protects against arboviral infection in the mosquito vector Aedes aegypti

F. Almire, S. Terry, M. McFarlane, A. Szemiel, S. Terhzaz, M. Varjak, A. McDonald, A. Kohl, E. Pondeville

This study shows that sugar feeding enhances antiviral immunity in Aedes aegypti mosquitoes, reducing arbovirus transmission potential.

bioRxiv · Jan 5, 2021Physiology

Adaptation to host cell environment during experimental evolution of Zika virus

V. Grass, E. Hardy, K. Kobert, S. R. Talemi, E. Decembre, C. Guy, P. V. Markov, A. Kohl, M. Paris, A. Böckmann, S. Munoz-Gonzalez, L. Sherry, T. Höfer, B. Boussau, M. Dreux

This study identifies genetic adaptations in Zika virus during experimental evolution in host cells, revealing increased infectivity and resistance to TLR3-induced restriction.

bioRxiv · Dec 28, 2020Microbiology

Insights into molecular evolution recombination of pandemic SARS-CoV-2 using Saudi Arabian sequences

I. Nour, I. O. Alanazi, A. Hanif, A. Kohl, S. A. Eifan

This study analyzes SARS-CoV-2 sequences from Saudi Arabia to investigate their origin, showing they are closely related to bat SARS-like coronaviruses and reveal recombination events and positive selection pressures.

bioRxiv · May 13, 2020 · PreprintMicrobiology

Population genomics of louping ill virus provide new insights into the evolution of tick-borne flaviviruses

J. J. Clark, J. Gilray, R. J. Orton, M. Baird, G. S. Wilkie, A. da Silva Filipe, N. Johnson, C. J. McInnes, A. Kohl, R. Biek

This study sequences 22 louping ill virus isolates to analyze genomic diversity and evolutionary history, finding low diversity, limited positive selection, and challenges in estimating molecular clock rates for tick-borne flaviviruses.

bioRxiv · Feb 14, 2020Evolutionary Biology

The Mosquito Electrocuting Trap As An Exposure-Free Method For Measuring Human Biting Rates By Aedes Mosquito Vectors

L. D. Ortega-Lopez, E. D. Pondeville, A. Kohl, R. Leon, M. Pazmino Betancourth, F. Almire, S. Torres Valencia, S. Saldarriaga, N. Mirzai, H. M. Ferguson

This study compares the Mosquito Electrocuting Trap (MET) to the BG-sentinel trap for measuring Aedes aegypti biting rates and finds no significant difference in abundance but highlights MET's potential for direct human biting rate measurement.

bioRxiv · Nov 2, 2019Ecology