Cell BiologybioRxivPreprint
IRE-1α is a key switch of pyroptosis and necroptosis in mice by dominating Gasdermin D
Z. Xin, Z. Qing, L. D. Yong…·Y. Chen
This study shows IRE-1α regulates both necroptosis and pyroptosis in mice by modulating GSDMD activity, with implications for therapeutic targeting in tissue injuries.
DOI 10.1101/2022.10.12.511926