Author

L. Zimmermann

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 3 Immunology· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:host-pathogen & immune response· 6 Approach:experimental assay· 4 Organism:human· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1 Assay:imaging· 1 Assay:metagenomics· 1

Frequent Co-Authors

P. Chlanda· 3 shared F. Graw· 2 shared O. T. Fackler· 2 shared R. Bartenschlager· 2 shared A. Imle· 1 shared A. Jost· 1 shared A. Oxenius· 1 shared A. Savarino· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersMicrobiology

P. Chlanda

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

A tissue-intrinsic mechanism sensitizes HIV-1 particles for TLR-triggered innate immune responses

S. Sid Ahmed, L. Zimmermann, A. Imle, K. Wuebben, N. Tibroni, L. Rauch-Wirth, J. Muench, P. Chlanda, F. Graw, O. T. Fackler

The paper identifies a tissue-intrinsic mechanism where the extracellular matrix restricts HIV-1 infectivity and enhances innate immune detection through conformational changes in viral Env and TLR recognition.

bioRxiv · Nov 22, 2023Immunology

The role of pneumococcal extracellular vesicles on the pathophysiology of the kidney disease Hemolytic Uremic Syndrome

M. Battista, B. Hoffmann, Y. Bachelot, L. Zimmermann, L. Teuber, A. Jost, S. Linde, M. Westermann, M. M. Müller, H. Slevogt, S. Hammerschmidt, M. T. Figge, C. Vilhena, P. F. Zipfel

This paper investigates the role of pneumococcal extracellular vesicles in the pathogenesis of hemolytic uremic syndrome and identifies their cargo and effects on host cells.

bioRxiv · Jan 30, 2023Microbiology

SARS-CoV-2 nsp3-4 suffice to form a pore shaping replication organelles

L. Zimmermann, X. Zhao, J. Makroczyova, M. Wachsmuth-Melm, V. Prasad, R. Bartenschlager, P. Chlanda

The paper identifies nsp3-4 as the minimal components forming a DMV-spanning pore in SARS-CoV-2 replication organelles, critical for membrane curvature and DMV formation.

bioRxiv · Oct 21, 2022 · PreprintMicrobiology

Adipogenic activity of chemicals used in plastic consumer products

J. Voelker, F. Ashcroft, A. Vedoy, L. Zimmermann, M. Wagner

The paper identifies MDCs in everyday plastics that promote adipogenesis, suggesting plastics as an underestimated contributor to obesity.

bioRxiv · Jul 29, 2021Pharmacology & Toxicology

The FDA-approved drug cobicistat synergizes with remdesivir to inhibit SARS-CoV-2 replication

I. L. Shytaj, M. Fares, B. Lucic, L. Gallucci, M. M. Tolba, L. Zimmermann, A. T. Ayoub, M. Cortese, C. J. Neufeldt, V. Laketa, P. Chlanda, O. T. Fackler, S. Boulant, R. Bartenschlager, M. Stanifer, , M. Lusic

This study shows that cobicistat synergizes with remdesivir to inhibit SARS-CoV-2 replication in cell lines and organoids, reducing viral replication to levels comparable to uninfected cells.

bioRxiv · Mar 9, 2021Microbiology

Locally confined IFNγ production by CD4+ T cells provides niches for murine cytomegalovirus replication in the salivary gland

J. Oderbolz, N. Zangger, L. Zimmermann, I. Sandu, J. Starruss, F. Graw, A. Oxenius

This study shows that CD4+ T cells produce IFNγ locally in clusters near MCMV infection foci in salivary glands, enabling regional protection while allowing continued viral replication.

bioRxiv · Jan 14, 2021 · PreprintImmunology