Author

P. Chlanda

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 6 Cell Biology· 2 Biochemistry· 1 Biophysics· 1 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:host-pathogen & immune response· 6 Research Focus:cell type annotation· 5 Approach:experimental assay· 5 Approach:microscopy & imaging analysis· 5 Assay:cryo-EM· 4 Organism:human· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:protein folding & dynamics· 2

Frequent Co-Authors

S. L. Winter· 6 shared L. Zimmermann· 3 shared M. Wachsmuth-Melm· 3 shared O. T. Fackler· 3 shared R. Bartenschlager· 3 shared S. Klein· 3 shared B. Bruegger· 2 shared C. J. Neufeldt· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

6 shared papersMicrobiology

S. L. Winter

Mutual co-authors in cluster

Author profile →

11 papers

Recent·Most cited

A tissue-intrinsic mechanism sensitizes HIV-1 particles for TLR-triggered innate immune responses

S. Sid Ahmed, L. Zimmermann, A. Imle, K. Wuebben, N. Tibroni, L. Rauch-Wirth, J. Muench, P. Chlanda, F. Graw, O. T. Fackler

The paper identifies a tissue-intrinsic mechanism where the extracellular matrix restricts HIV-1 infectivity and enhances innate immune detection through conformational changes in viral Env and TLR recognition.

bioRxiv · Nov 22, 2023Immunology

Nucleocapsid condensation drives Ebola viral factory maturation and dispersion

M. Vallbracht, B. S. Bodmer, K. Fischer, S. L. Winter, L. Wendt, M. Wachsmuth-Melm, T. Hoenen, P. Chlanda

This study uses cryo-ET to show that Ebola virus nucleocapsids transition from loose helical structures to condensed cylinders, driving viral factory maturation and dispersion.

bioRxiv · Nov 6, 2023 · PreprintMicrobiology

Disulfide bridge-dependent dimerization triggers FGF2 membrane translocation into the extracellular space

F. Lolicato, J. Steringer, R. Saleppico, D. Beyer, J. Fernandez-Sobaberas, S. Unger, S. Klein, P. Riegerova, X. J. Schmitt, S. Kaptan, S. Wegehingel, H.-M. Mueller, C. Freund, M. Hof, R. Sachl, , W. Nickel

This paper identifies C95-C95 disulfide-bridge-mediated FGF2 dimerization as essential for membrane translocation and oligomer formation, while C77 is involved in Na,K-ATPase binding.

bioRxiv · Apr 12, 2023Biochemistry

SARS-CoV-2 nsp3-4 suffice to form a pore shaping replication organelles

L. Zimmermann, X. Zhao, J. Makroczyova, M. Wachsmuth-Melm, V. Prasad, R. Bartenschlager, P. Chlanda

The paper identifies nsp3-4 as the minimal components forming a DMV-spanning pore in SARS-CoV-2 replication organelles, critical for membrane curvature and DMV formation.

bioRxiv · Oct 21, 2022 · PreprintMicrobiology

The Ebola virus VP40 matrix undergoes endosomal disassembly essential for membrane fusion

S. L. Winter, G. Golani, F. Lolicato, M. Vallbracht, K. Thiyagarajah, S. S. Ahmed, C. Luechtenborg, O. T. Fackler, B. Bruegger, T. Hoenen, W. Nickel, U. S. Schwarz, P. Chlanda

This study shows that Ebola virus VP40 matrix disassembles in endosomes due to pH changes, facilitating membrane fusion and viral entry.

bioRxiv · Aug 24, 2022 · PreprintMicrobiology

The glycolipid GlcCer is recruited into the viral envelope to promote phenuivirus binding to host cells

Z. M. Uckeley, M. Mazelier, C. Luechtenborg, S. L. Winter, P. Schad, P. Chlanda, B. Bruegger, P.-Y. Lozach

This study identifies GlcCer as a viral glycolipid essential for phenuivirus binding to host cells, showing its role in viral attachment and receptor identification.

bioRxiv · Aug 7, 2022Microbiology

Dual-axis Volta phase plate cryo-electron tomography of Ebola virus-like particles reveals actin-VP40 interactions

S. L. Winter, P. Chlanda

This study uses dual-axis Volta phase plate cryo-ET to analyze Ebola virus-like particles, revealing actin-VP40 interactions and improved 3D structural insights.

bioRxiv · Apr 21, 2021Biophysics

The FDA-approved drug cobicistat synergizes with remdesivir to inhibit SARS-CoV-2 replication

I. L. Shytaj, M. Fares, B. Lucic, L. Gallucci, M. M. Tolba, L. Zimmermann, A. T. Ayoub, M. Cortese, C. J. Neufeldt, V. Laketa, P. Chlanda, O. T. Fackler, S. Boulant, R. Bartenschlager, M. Stanifer, , M. Lusic

This study shows that cobicistat synergizes with remdesivir to inhibit SARS-CoV-2 replication in cell lines and organoids, reducing viral replication to levels comparable to uninfected cells.

bioRxiv · Mar 9, 2021Microbiology

SARS-CoV-2 structure and replication characterized by in situ cryo-electron tomography

S. Klein, M. Cortese, S. L. Winter, M. Wachsmuth-Melm, C. J. Neufeldt, B. Cerikan, M. L. Stanifer, S. Boulant, R. Bartenschlager, P. Chlanda

This study uses in situ cryo-electron tomography to visualize SARS-CoV-2 replication compartments and virion structure, revealing RNA filament organization and vRNP packaging mechanisms.

bioRxiv · Jun 23, 2020Microbiology

Post-correlation on-lamella cryo-CLEM reveals the membrane architecture of lamellar bodies

S. Klein, B. H. Wimmer, S. L. Winter, A. Kolovou, V. Laketa, P. Chlanda

The paper uses cryo-CLEM to study lamellar bodies in their unperturbed state, revealing their membrane architecture and a new outer membrane dome protein complex.

bioRxiv · Feb 27, 2020Cell Biology

Multiplexed electron microscopy by fluorescent barcoding allows screening for ultrastructural phenotype

Y. Bykov, N. Cohen, N. Gabrielli, H. Manenschijn, S. Welsch, P. Chlanda, W. Kukulski, K. R. R. Patil, M. Schuldiner, J. A. G. Briggs

The paper introduces a method using fluorescent barcoding and electron microscopy to enable high-throughput screening of ultrastructural phenotypes in yeast.

Journal of Cell Biology · Aug 5, 2019Peer-reviewedCell Biology