Author

M. Altfeld

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Assay:flow cytometry· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

A. Grundhoff· 1 shared A. Werner· 1 shared D. Sikuku· 1 shared E. S. Lander· 1 shared G. Tweet· 1 shared H. L. Dugan· 1 shared J. Ghofrani· 1 shared J. Kombo· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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1 shared paperImmunology

A. Grundhoff

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Author profile →

3 papers

Recent·Most cited

Altered glucose utilization and disrupted mitochondrial homeostasis in CD4+ T cells from HIV-positive women on combination anti-retroviral therapy

M. Akiso, M. Ameka, K. Naidoo, R. Langat, J. Kombo, D. Sikuku, T. Ndung'u, M. Altfeld, O. Anzala, M. Mureithi

This study examines metabolic changes in immune cells of HIV-positive women on antiretroviral therapy, finding altered glucose uptake and increased mitochondrial activity in CD4+ T cells.

bioRxiv · May 17, 2023 · PreprintImmunology

Human antigen-specific memory natural killer cell responses develop against HIV-1 and influenza virus and are dependent on MHC-E restriction

S. Jost, O. Lucar, T. Yoder, K. Kroll, S. Sugawara, S. Smith, R. Jones, G. Tweet, A. Werner, P. J. Tomezsko, H. L. Dugan, J. Ghofrani, M. Altfeld, A. Grundhoff, M. Muller-Trutwin, , R. K. Reeves

This study shows human NK cells develop antigen-specific memory against HIV-1 and influenza via MHC-E restriction, validated through single-cell cloning and biomarker analysis.

bioRxiv · Nov 9, 2020 · PreprintImmunology

Applying CRISPR-based genetic screens to identify drivers of tumor-cell sensitivity towards NK-cell attack

K. Klein, T. Wang, E. S. Lander, M. Altfeld, W. F. Garcia-Beltran

This study uses CRISPR-based screens to identify factors that enhance NK-cell cytotoxicity against tumor cells, finding B7H6 as a key ligand for NKp30.

bioRxiv · Jan 27, 2019 · PreprintImmunology