Author

K. Kroll

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:flow cytometry· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

R. K. Reeves· 3 shared C. Manickam· 2 shared R. Jones· 2 shared S. Jost· 2 shared S. Smith· 2 shared T. Yoder· 2 shared A. Chandrashekar· 1 shared A. Grundhoff· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersImmunology

R. K. Reeves

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Author profile →

4 papers

Recent·Most cited

Upregulation of the NKG2D ligand ULBP2 by JC polyomavirus infection promotes immune recognition by natural killer cells.

S. Jost, J. Ahn, S. Chen, T. Yoder, K. E. Gikundiro, E. Lee, S. B. Gressens, K. Kroll, M. Craemer, G. C. Kaynor, M. Lifton, C. S. Tan

This study shows that NK cells can eliminate JCPyV-infected cells through NKG2D-ULBP2 interaction, suggesting this pathway as a potential immunotherapeutic target for PML.

The Journal of Infectious Diseases · Sep 29, 2023Peer-reviewedImmunology

A Novel CRISPR-Engineered, Stem Cell-Derived Cellular Vaccine

K. Chakraborty, A. Chandrashekar, A. Sidaway, E. Latta, J. Yu, K. McMahan, C. Manickam, K. Kroll, M. Mosher, R. K. Reeves, R. Gam, E. Arthofer, M. Choudhry, D. H. Barouch, T. Henley

This paper describes a CRISPR-engineered cellular vaccine designed to mimic natural immunity, showing robust neutralizing antibody responses and reduced viral load in non-human primates.

bioRxiv · Dec 28, 2021 · PreprintImmunology

Systemic and mucosal mobilization of granulocyte subsets during lentivirus infection

R. Jones, C. Manickam, D. R. Ram, K. Kroll, B. Hueber, G. Woolley, S. V. Shah, S. Smith, V. Varner, R. K. Reeves

This study examines granulocyte subset dynamics in systemic and mucosal tissues during lentivirus infection in rhesus macaques, finding altered frequencies in chronic infection, particularly in gastrointestinal mucosae.

bioRxiv · Mar 19, 2021Immunology

Human antigen-specific memory natural killer cell responses develop against HIV-1 and influenza virus and are dependent on MHC-E restriction

S. Jost, O. Lucar, T. Yoder, K. Kroll, S. Sugawara, S. Smith, R. Jones, G. Tweet, A. Werner, P. J. Tomezsko, H. L. Dugan, J. Ghofrani, M. Altfeld, A. Grundhoff, M. Muller-Trutwin, , R. K. Reeves

This study shows human NK cells develop antigen-specific memory against HIV-1 and influenza via MHC-E restriction, validated through single-cell cloning and biomarker analysis.

bioRxiv · Nov 9, 2020 · PreprintImmunology