Upregulation of the NKG2D ligand ULBP2 by JC polyomavirus infection promotes immune recognition by natural killer cells.
S. Jost, J. Ahn, S. Chen, T. Yoder, K. E. Gikundiro, E. Lee, S. B. Gressens, K. Kroll, M. Craemer, G. C. Kaynor, M. Lifton, C. S. Tan
This study shows that NK cells can eliminate JCPyV-infected cells through NKG2D-ULBP2 interaction, suggesting this pathway as a potential immunotherapeutic target for PML.
bioRxiv · May 31, 2023Immunology