Discovery of SARS-CoV-2 papain-like protease inhibitors through a combination of high-throughput screening and FlipGFP-based reporter assay
Z. Xia, M. Sacco, C. Ma, J. Townsend, N. Kitamura, Y. Hu, M. Ba, T. Szeto, X. Zhang, X. Meng, F. Zhang, Y. Xiang, M. Marty, Y. Chen, J. Wang
This study identifies potent SARS-CoV-2 PLpro inhibitors through high-throughput screening and a FlipGFP-based assay, showing improved antiviral activity compared to existing compounds.
bioRxiv · Mar 15, 2021Pharmacology & Toxicology