Author

T. Szeto

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1 Organism:virus· 1

Frequent Co-Authors

C. Ma· 3 shared J. Wang· 3 shared Y. Hu· 3 shared B. Hurst· 2 shared B. Tarbet· 2 shared X. ZhangiD· 2 shared Y. Chen· 2 shared F. Zhang· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersPharmacology & Toxicology

C. Ma

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Author profile →

3 papers

Recent·Most cited

Discovery of SARS-CoV-2 papain-like protease inhibitors through a combination of high-throughput screening and FlipGFP-based reporter assay

Z. Xia, M. Sacco, C. Ma, J. Townsend, N. Kitamura, Y. Hu, M. Ba, T. Szeto, X. Zhang, X. Meng, F. Zhang, Y. Xiang, M. Marty, Y. Chen, J. Wang

This study identifies potent SARS-CoV-2 PLpro inhibitors through high-throughput screening and a FlipGFP-based assay, showing improved antiviral activity compared to existing compounds.

ACS Central Science · Jun 18, 2021Peer-reviewedPharmacology & Toxicology

Boceprevir, calpain inhibitors II and XII, and GC-376 have broad-spectrum antiviral activity against coronaviruses in cell culture

Y. Hu, C. Ma, T. Szeto, B. Hurst, B. Tarbet, J. Wang

This study identifies four compounds with broad-spectrum antiviral activity against multiple coronaviruses, including SARS-CoV-2, by inhibiting viral Mpro and cathepsin L.

bioRxiv · Oct 30, 2020Pharmacology & Toxicology

Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease

C. Ma, M. D. Sacco, B. Hurst, J. A. Townsend, Y. Hu, T. Szeto, X. Zhang, B. Tarbet, M. T. Marty, Y. Chen, J. Wang

This study identifies inhibitors of SARS-CoV-2 main protease that show potent antiviral activity in cell culture.

Cell Research · Jun 15, 2020Peer-reviewedPharmacology & Toxicology