Author

M. Bashton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

A. Hamblin· 2 shared A. J. Mead· 2 shared A. Rodriguez-Meira· 2 shared B. Psaila· 2 shared C. Harrison· 2 shared I. Antony-Debre· 2 shared M. Crown· 2 shared M. Drummond· 2 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersCancer Biology

A. Hamblin

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

TRIM7 ubiquitinates SARS-CoV-2 membrane protein to limit apoptosis and viral replication

M. Gonzalez-Orozco, H.-c. Tseng, A. Hage, H. Xia, P. Behera, K. Afreen, Y. Penaflor-Tellez, M. I. Giraldo, M. Huante, L. Puebla-Clark, S. van Tol, A. Odle, M. Crown, N. Teruel, T. R. Shelite, , R. Rajsbaum

This study identifies TRIM7 as an E3-ubiquitin ligase that ubiquitinates SARS-CoV-2 M protein to inhibit apoptosis and viral replication.

bioRxiv · Jun 17, 2024Microbiology

Chromothripsis orchestrates leukemic transformation in blast phase MPN through targetable amplification of DYRK1A

C. K. Brierley, B. H. Yip, G. Orlando, H. Goyal, S. Wen, J. Wen, M. F. Levine, M. G. Jakobsdottir, A. Rodriguez-Meira, A. Adamo, M. Bashton, A. Hamblin, S. A. Clark, J. O'Sullivan, L. Murphi, , A. J. Mead

The paper identifies chromothripsis-induced amplification of DYRK1A in blast phase MPN as a driver of aggressive disease and a potential therapeutic target.

bioRxiv · Dec 8, 2023 · PreprintCancer Biology

Deciphering TP53 mutant Cancer Evolution with Single-Cell Multi-Omics

A. Rodriguez-Meira, R. Norfo, W. X. Wen, A. L. Chedeville, H. Rahman, J. OSullivan, G. Wang, E. Louka, W. Kretzschmar, A. Paterson, C. Brierley, J.-E. Martin, C. Demeule, M. Bashton, N. Sousos, , A. J. Mead

The paper uses single-cell multi-omic analysis to study TP53-mutant cancer evolution in leukaemia, identifying a role for chronic inflammation in promoting TP53 mutant clones.

bioRxiv · Mar 28, 2022 · PreprintCancer Biology

Computational analysis of the effect of SARS-CoV-2 variant Omicron Spike protein mutations on dynamics, ACE2 binding and propensity for immune escape

N. Teruel, M. Crown, M. Bashton, R. Najmanovich

This paper evaluates how Omicron SARS-CoV-2 Spike protein mutations affect ACE2 binding and immune escape by analyzing structural dynamics and binding interactions.

bioRxiv · Dec 14, 2021 · PreprintBiophysics