M. Berard

Mice Humanized for Major Histocompatibility Complex and Angiotensin-Converting Enzyme 2 with High Permissiveness to SARS-CoV-2 Omicron Replication

This paper develops hACE2 transgenic mice with high permissiveness to SARS-CoV-2 Omicron replication and uses them to test a vaccine candidate.

Fungal zygote survival and ploidy maintenance rely on cell cycle-dependent and independent mating blocks

This study identifies two mechanisms in fission yeast that prevent zygotic mating and maintain ploidy: Mei2 enforcing meiosis and Mei3 driving cell cycle progression.

The spatial heterogeneity of the gut limits bacteriophage predation leading to the coexistence of antagonist populations of bacteria and their viruses

The paper shows that spatial heterogeneity in the gut allows bacteria to coexist with their phages by providing refuge sites, challenging previous assumptions about phage-bacteria dynamics.

A toolbox of Stable Integration Vectors (SIV) in the fission yeast Schizosaccharomyces pombe

The paper develops a modular toolbox of Stable Integration Vectors (SIV) for fission yeast to enable precise, stable genomic integration of heterologous sequences.

Innate immune recognition of a bacterial MAMP leads to conditional activation of pro- or anti-inflammatory responses

This study shows that flagellin, a bacterial MAMP, can trigger either pro- or anti-inflammatory responses depending on the tissue's physiological state and context.

Specific targeting of intestinal Prevotella copri by a Listeria monocytogenes bacteriocin

This study identifies a Listeria bacteriocin that specifically targets Prevotella copri, showing microbiota-dependent effects on Listeria infection in mice.

Excess calorie intake early in life increases susceptibility to colitis in the adult

The paper shows that early-life excess calorie intake increases adult susceptibility to colitis through mechanisms involving intestinal permeability, inflammation, and microbial hydrogen sulfide production.