Author

R. Smits

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Organism:human· 2 Research Focus:host-pathogen & immune response· 1 Assay:protein structure· 1

Frequent Co-Authors

A. Gewirtz· 1 shared A. Hayashi· 1 shared A. Kikuchi· 1 shared A. Niida· 1 shared B. Chassaing· 1 shared B.-C. Chen· 1 shared E. Betzig· 1 shared F. Dejardin· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperImmunology

A. Gewirtz

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Lack of dominant-negative activity for tumor-associated ZNRF3 missense mutations at endogenous expression levels

S. Li, J. Niu, R. Zhang, S. Massaar, J. v. Merode, N. d. Schipper, L. v. d. Kamp, M. P. Peppelenbosch, R. Smits

This study shows that tumor-associated ZNRF3 missense mutations do not exhibit dominant-negative activity and instead act as loss-of-function mutations at endogenous levels.

bioRxiv · Mar 14, 2024Cancer Biology

Adaptive fitness in APC-mutant cells requires chromosome rearrangements

Y. Kawasaki, T. Hamaji, K. Owada, A. Hayashi, Y. Wu, T. Nogi, M. Okada, S. Sakai, N. Tokushige, S. Sasagawa, H. Nakagawa, Y. Kouyama, A. Niida, K. Mimori, T. Kuroda, , Y. Mimori-Kiyosue

The paper shows that APC-mutant cells gain adaptive fitness through chromosome rearrangements that restore AURKA activity and counteract mitotic defects.

bioRxiv · Sep 18, 2020 · PreprintCell Biology

Innate immune recognition of a bacterial MAMP leads to conditional activation of pro- or anti-inflammatory responses

J. H. Park, S. Cornick, G. Nigro, G. Bertin, F. Dejardin, R. Smits, M. Berard, F. Langa Vives, I. Gomperts Boneca, A. Gewirtz, B. Chassaing, N. Barnich, P. Sansonetti, G. Eberl

This study shows that flagellin, a bacterial MAMP, can trigger either pro- or anti-inflammatory responses depending on the tissue's physiological state and context.

bioRxiv · Jul 28, 2019 · PreprintImmunology