Author

M. Breen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Organism:human· 3 Approach:statistical model· 3 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:clustering· 1

Frequent Co-Authors

A. J. Schulte· 2 shared A. L. Sarver· 2 shared C. L. Foster· 2 shared J. F. Modiano· 2 shared J. H. Kim· 2 shared K. Lindblad-Toh· 2 shared L. Oseth· 2 shared N. Cheng· 2 shared

Activity by Year

2017-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersCancer Biology

A. J. Schulte

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Author profile →

4 papers

Recent·Most cited

Inflammatory markers in pregnancy - surprisingly stable. Mapping trajectories and drivers in four large cohorts.

F. A. J. Gigase, A. Suleri, E. Isaevska, A.-S. Rommel, M. G. B. M. Boekhorst, O. Dmitrichenko, H. El Marroun, E. A. P. Steegers, M. H. J. Hillegers, R. L. Muetzel, W. Lieb, C. A. M. Cecil, V. J. M. Pop, M. Breen, V. Bergink, L. D. de Witte

This study examines inflammatory markers during pregnancy across four cohorts, finding that cytokines show high individual stability and genetic influence, while CRP is more influenced by BMI and polygenic factors.

bioRxiv · Jun 19, 2024 · PreprintImmunology

Hemangiosarcoma Cells Promote Conserved Host-Derived Hematopoietic Expansion

J. H. Kim, A. J. Schulte, A. L. Sarver, M. G. Angelos, A. M. Frantz, C. L. Foster, T. D. O'Brien, I. Cornax, M. G. O'Sullivan, N. Cheng, M. Lewellen, L. Oseth, S. Kumar, S. Bullman, C. S. Pedamallu, , J. F. Modiano

This study shows that hemangiosarcoma cells create a microenvironment that supports hematopoietic expansion, resembling bone marrow niche cells.

bioRxiv · May 21, 2021Cancer Biology

Genomically Complex Human Angiosarcoma and Canine Hemangiosarcoma Establish Convergent Angiogenic Transcriptional Programs Driven by Novel Gene Fusions

J. H. Kim, K. J. Megquier, R. Thomas, A. L. Sarver, J. M. Song, Y. T. Kim, A. J. Schulte, N. Cheng, M. A. Linden, P. Murugan, L. Oseth, C. L. Foster, I. Elvers, R. Swofford, J. Turner-Maier, , J. F. Modiano

This study identifies novel fusion genes in human angiosarcomas and canine hemangiosarcomas, showing convergent transcriptional programs driven by these fusions and mutations in TP53 and PI3K/AKT/mTOR pathway genes.

bioRxiv · Aug 11, 2020Cancer Biology

Somatic inactivating PTPRJ mutations and dysregulated pathways identified in canine melanoma by integrated comparative genomic analysis

W. P. D. Hendricks, V. Zismann, K. Sivaprakasam, C. Legendre, K. Poorman, W. Tembe, J. Kiefer, W. Liang, V. DeLuca, M. Stark, A. Ruhe, R. Froman, N. Duesbury, M. Washington, J. Aldrich, , J. Trent

This study identifies somatic PTPRJ mutations and dysregulated pathways in canine melanoma through genomic analysis, revealing similarities with human melanoma subtypes and potential therapeutic targets.

bioRxiv · Sep 30, 2017Cancer Biology