J. Young

Prevalence of the Calvin-Benson-Bassham cycle in chemolithoautotrophic psychrophiles and the potential for cold-adapted Rubisco

This paper identifies the Calvin-Benson-Bassham cycle as the dominant chemolithoautotrophic pathway in subzero environments and explores cold-adapted Rubisco variants in psychrophilic bacteria.

Pathogenic Bacteroides fragilis strains can emerge from gut-resident commensals

This study identifies genetic factors enabling Bacteroides fragilis to transition from commensal to pathogenic by analyzing 813 strains and their genomic diversity.

A Binary RNA and DNA Self-Amplifying Platform for Next Generation Vaccines and Therapeutics

This paper introduces a binary RNA and DNA self-amplifying platform that enhances vaccine effectiveness, reduces cost, and simplifies manufacturing and distribution.

BINANA 2.0: Characterizing Protein/Ligand Interactions in Python and JavaScript

BINANA 2.0 provides a web-based tool for analyzing protein/ligand interactions using Python and JavaScript, enabling visualization and analysis in web browsers.

Effects of CO2 and RuBisCO concentration on cyanobacterial growth and carbon isotope fractionation

This study investigates how CO2 and RuBisCO concentration affect cyanobacterial growth and carbon isotope fractionation by engineering a RuBisCO-overexpressing mutant strain.

Forecasting the effects of water regulation on the population viability of a threatened amphibian

This study models how river regulation affects the extinction risk of southern bell frogs by simulating inundation patterns and population dynamics under different scenarios.

Aberrant Epithelial Differentiation Contributes to Pathogenesis in a Murine Model of Congenital Tufting Enteropathy

This study shows that loss of EpCAM in CTE mice leads to altered intestinal cell differentiation, increasing absorptive cells and decreasing secretory cells, which can be partially reversed by DAPT treatment.

Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases

The paper reveals conserved interaction rules between RNA helicases and TRIM E3 ligases in vertebrate innate immunity using cryo-EM and biochemistry.

Validating the use of bovine buccal sampling as a proxy for the rumen microbiota using a time course and random forest classification approach

This paper validates buccal swab sampling as a non-invasive proxy for rumen microbiota by optimizing sampling timing and using random forest classification to identify discriminatory taxa.

Differential protein phosphorylation affects the localisation of two secreted Toxoplasma proteins and is widespread during stage conversion

This paper investigates the role of phosphorylation in regulating the localization of two secreted Toxoplasma proteins during stage conversion and identifies widespread differential phosphorylation of secreted proteins.

Positional dynamics and glycosomal recruitment of developmental regulators during trypanosome differentiation

The paper tracks TbPIP39 recruitment to glycosomes during trypanosome differentiation and identifies a regulatory site coordinating signaling and glycosomal development.

Laboratory contamination over time during low-biomass sample analysis

This study examines laboratory contamination in low-biomass samples over time, finding that contaminants vary by lab, season, and extraction method, and recommends controls and reporting to mitigate their impact.