M. L. Reese

The paper identifies Mmc1, a DRP-like pseudoenzyme that interacts with MICOS to maintain cristae architecture in S. pombe.

This study uses cryo-electron tomography to show that the apical complex in apicomplexan parasites moves as a rigid body, with the conoid structure remaining unchanged during protrusion and retraction.

This study identifies two phosphosites on the kinase WNG1 that are essential for its activity and reveals that its activation is triggered by increased ATP concentration upon trafficking to the parasitophorous vacuole.

This study identifies multivalent interactions among AC9, AC10, and ERK7 that stabilize the apical complex in Toxoplasma, concentrating ERK7 kinase activity in the apical cap.

This study identifies ERK7 and CSAR1 as critical for apical complex stability in Toxoplasma gondii, showing CSAR1's role in maternal cytoskeleton turnover and its mislocalization affecting parasite replication.

The paper identifies AC9 as an essential scaffold for ERK7 regulation during apical complex biogenesis in Toxoplasma gondii, revealing a novel inhibitory mechanism for an ancient MAPK.

This study identifies MAPK2 as essential for Toxoplasma gondii cell division by regulating centrosome duplication, leading to parasite death when MAPK2 is lost.

The paper identifies ERK7 as essential for conoid assembly in Toxoplasma gondii, causing severe defects in parasite motility and invasion.

This study identifies NLRP3-dependent but inflammasome-independent pathways regulating CD8 T cell IFNγ responses to Toxoplasma gondii vacuolar antigens, independent of ROP5 virulence factors.