S100A1ct: a synthetic peptide derived from human S100A1 protein improves cardiac contractile performance and survival in pre-clinical heart failure models
D. Kehr, J. Ritterhoff, M. Glaser, L. Jarosch, R. Salazar, K. Spaich, K. Varadi, J. Birkenstock, M. Egger, E. Gao, W. J. Koch, H. A. Katus, N. Frey, A. Jungmann, C. Busch, , P. Most
This paper develops a synthetic peptide S100A1ct that improves cardiac function and survival in heart failure models by enhancing Ca2+ cycling and targeting SERCA2a and RyR2.
bioRxiv · Mar 4, 2023Pharmacology & Toxicology