Mouse Model of Heart Attack and Stroke Shows Improved Survival with MPO Inhibition
S. Shamsuzzaman, R. A. Deaton, H. Doviak, M. Evans, A. Salamon, S. Karnewar, V. Serbulea, G. F. Alencar, L. S. Shankman, K. Walsh, S. Bekiranov, O. Kocher, M. Kreiger, B. Kull, M. Persson, , G. K. Owens
The paper introduces a mouse model of advanced atherosclerosis that exhibits spontaneous plaque rupture leading to MI or stroke, and shows that MPO inhibition with AZM198 reduces mortality and plaque rupture incidence.
Circulation · Aug 27, 2024Peer-reviewedPhysiology