Coronavirus endoribonuclease nsp15 induces host cellular protein synthesis shutoff
Y. Liao, X. Gong, S. Feng, B. Gao, S. Fang, W. Weng, H. Chu, Y. Yuan, Y. Cheng, Y. Sun, L. Tan, C. Song, X. Qiu, C. Ding, M. Liao, , M. Forlenza
This study shows that coronavirus nsp15 inhibits host protein synthesis and targets host mRNA, with EndoU activity essential for these effects and virus replication.
bioRxiv · Mar 20, 2023 · PreprintMicrobiology