H. Chu

Coronavirus Nucleocapsid Protein Enhances the binding of p-PKCα to RACK1: Implications for Inhibition of Nucleocytoplasmic Trafficking and Suppression of the Innate Immune Response

This study identifies how the coronavirus N protein disrupts nucleocytoplasmic trafficking and suppresses the innate immune response by promoting RACK1-PKC interaction and NUP62 phosphorylation.

Pathogenic Bacteroides fragilis strains can emerge from gut-resident commensals

This study identifies genetic factors enabling Bacteroides fragilis to transition from commensal to pathogenic by analyzing 813 strains and their genomic diversity.

Potent and broadly neutralizing antibodies against sarbecoviruses elicited by single ancestral SARS-CoV-2 infection

This study identifies two broadly neutralizing antibodies against SARS-CoV-2 and related sarbecoviruses from individuals exposed only to ancestral SARS-CoV-2.

Persistent lung inflammation and alveolar-bronchiolization due to Notch signaling dysregulation in SARS-CoV-2 infected hamster

This study shows SARS-CoV-2 infection in hamsters causes persistent lung inflammation and alveolar-bronchiolization linked to Notch signaling dysregulation and potential cancer risk.

Potent and broadly neutralizing antibodies against sarbecoviruses induced by sequential COVID-19 vaccination

This study identifies potent and broadly neutralizing antibodies against SARS-CoV-2 and related sarbecoviruses from a vaccinated donor, showing their efficacy against multiple variants and providing insights for therapeutic development.

The ecological relevance of flagellar motility in soil bacterial communities

This study investigates the ecological relevance of flagellar motility in soil bacteria by analyzing genomic and metagenomic data across multiple soil environments.

Persistent immune imprinting after XBB.1.5 COVID vaccination in humans

This study shows that immune imprinting from prior Wuhan-Hu-1 spike exposure persists after XBB.1.5 vaccine booster, with neutralizing antibodies dominated by pre-existing memory B cells.

BMP signaling maintains auricular chondrocyte identity and prevents microtia development by inhibiting protein kinase A

This study shows BMP signaling maintains auricular chondrocyte identity and prevents microtia by inhibiting PKA, through a switch from chondrogenic to osteogenic programs.

A bacterial sialidase mediates early life colonization by a pioneering gut commensal

This study identifies a bacterial sialidase, NanH, in Bacteroides fragilis that mediates early gut colonization and resilience through host-derived glycans.

A Taxonomically-informed Mass Spectrometry Search Tool for Microbial Metabolomics Data

MicrobeMASST identifies microbial-derived metabolites and their producers using taxonomically-informed mass spectrometry data without prior knowledge.

Coronavirus endoribonuclease nsp15 induces host cellular protein synthesis shutoff

This study shows that coronavirus nsp15 inhibits host protein synthesis and targets host mRNA, with EndoU activity essential for these effects and virus replication.

The global distribution of paired eddy covariance towers

The paper identifies 56% of global eddy covariance towers as paired, finds they sample richer soils and different climates than the global network, and highlights data gaps in certain regions and ecosystems.

Selective IL-27 production by intestinal regulatory T cells permits gut-specific regulation of Th17 immunity

This study identifies intestinal regulatory T cells producing IL-27 to specifically regulate Th17 immunity in the gut, revealing a novel mechanism for tissue-specific immune control.

Anamnestic Humoral Correlates of Immunity Across SARS-CoV-2 Variants of Concern

The paper identifies conserved S2-domain antibody responses in anamnestic immunity across SARS-CoV-2 variants, suggesting their role in viral clearance and vaccine design.

Spatiotemporal heterogeneity and the long-term impact of meteorological , environmental and socio-economic factors of scrub typhus in China from 2012 to 2018

This study analyzes the spatiotemporal patterns of scrub typhus in China from 2012 to 2018, identifying key meteorological, environmental, and socio-economic factors influencing its distribution.

Computation of Antigenicity Predicts SARS-CoV-2 Vaccine Breakthrough Variants

This paper develops a computational model to predict SARS-CoV-2 variant antigenicity from sequence data, showing high accuracy in predicting neutralisation titre decreases for known variants and Omicron.

The SARS-CoV-2 Omicron (B.1.1.529) variant exhibits altered pathogenicity, transmissibility, and fitness in the golden Syrian hamster model

The study compares the pathogenicity, transmissibility, and fitness of SARS-CoV-2 Omicron and Delta variants in golden Syrian hamsters, finding Omicron less pathogenic but more transmissible and capable of outcompeting Delta under immune pressure.

An elite broadly neutralizing antibody protects SARS-CoV-2 Omicron variant challenge

This study identifies a broadly neutralizing antibody, ZCB11, effective against SARS-CoV-2 Omicron and Delta variants, showing protection in hamsters.

Striking Antibody Evasion Manifested by the Omicron Variant of SARS-CoV-2

This study shows that the Omicron variant of SARS-CoV-2 is highly resistant to neutralization by convalescent serum and vaccines, and many monoclonal antibodies.

Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift

This study shows that Omicron variant's spike protein has enhanced ACE2 binding and reduces neutralizing activity, but some broadly neutralizing antibodies remain effective.

Isolation and comparative analysis of antibodies that broadly neutralize sarbecoviruses

The paper identifies a human monoclonal antibody that neutralizes all tested sarbecoviruses and describes a new antibody class with potential for pandemic preparedness.

Delta breakthrough infections elicit potent, broad and durable neutralizing antibody responses

The paper examines antibody responses in Delta breakthrough infections, finding they are more potent, durable, and broad compared to vaccinated-only or infected-only individuals.

Commensal bacteria promote type I interferon signaling to maintain immune tolerance

This study shows that commensal bacteria promote type I interferon signaling to support immune tolerance by enhancing T regulatory cell function.

Severe fever with thrombocytopenia syndrome virus and parthenogenetic Asian longhorned tick Haemaphysalis longicornis (Acari: Ixodidae)

The paper investigates the role of parthenogenetic Asian longhorned ticks in spreading SFTSV, finding they contribute to rapid spread and long-range movement.

SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters

This study shows SARS-CoV-2 infection causes bone loss in golden Syrian hamsters through cytokine dysregulation and osteoclastogenesis.

SARS-CoV-2 hijacks neutralizing dimeric IgA for enhanced nasal infection and injury

This study shows that dimeric IgA antibodies can enhance SARS-CoV-2 nasal infection and injury in Syrian hamsters by engaging CD209 as an alternative receptor.

Controllable drug release of pH-sensitive liposomes encapsulating artificial cytosol system

This paper develops an artificial cytosol system using agarose-sucrose to create pH-sensitive liposomes that enhance drug delivery efficiency.

Isolation and Characterization of Cross-Neutralizing Coronavirus Antibodies from COVID-19+ Subjects

The paper isolates and characterizes cross-neutralizing antibodies from COVID-19 patients, identifying antibodies that neutralize both SARS-CoV-1 and SARS-CoV-2, including variants.

Evaluating Specimen Quality and Results from a Community-Wide, Home-Based Respiratory Surveillance Study

The paper evaluates the quality of specimens and results from a home-based respiratory surveillance study to assess its feasibility for community-level monitoring of respiratory pathogens.

Co-evolution of Eukaryotic-like Vps4 and ESCRT-III Subunits in the Asgard Archaea

This study shows that Asgard archaea possess ESCRT complexes with eukaryotic-like structural and functional features, suggesting they are evolutionary precursors to eukaryotic ESCRTs.