S. Fang

Equilibrium Tension and Compression Mechanical Properties of the Human Uterus

This study measures the mechanical properties of the human uterus during non-pregnancy and late pregnancy under compression and tension, finding reduced stiffness and increased fiber extensibility in pregnant tissue.

The segmented flavivirus Alongshan virus reduces mitochondrial mass via degrading STAT2 to suppress innate immune response

Targeting GFPT2 to reinvigorate immunotherapy in EGFR-mutated NSCLC

This study identifies GFPT2 as a metabolic checkpoint in EGFR-mutated NSCLC that promotes immune evasion, and shows that targeting GFPT2 enhances PD-1 blockade therapy.

Herpes zoster mRNA vaccine induces superior vaccine immunity over licensed vaccine in mice and rhesus macaques

This study compares a novel VZV mRNA vaccine (ZOSAL) with Shingrix in mice and rhesus macaques, showing ZOSAL induces stronger T cell immunity and safety.

Material Properties of Nonpregnant and Pregnant Human Uterine Layers

This study measures time-dependent material properties of human uterine layers in nonpregnant and third-trimester pregnant tissues using nanoindentation.

Coronavirus endoribonuclease nsp15 induces host cellular protein synthesis shutoff

This study shows that coronavirus nsp15 inhibits host protein synthesis and targets host mRNA, with EndoU activity essential for these effects and virus replication.

Smart squirrels use a mortise-tenon structure to fix nuts on understory twigs

The paper describes how two species of flying squirrels in Hainan Island use a mortise-tenon structure to securely cache nuts on twigs to deter predation and ensure food supply.

Development of Equine Polyclonal Antibodies as a Broad-Spectrum Therapy Against SARS-CoV-2 Variants

This paper develops equine polyclonal antibodies that broadly neutralize major SARS-CoV-2 variants, showing high efficacy in vitro and ex vivo with low cost and potential for large-scale production.

A latitudinal pattern of plant leaf-associated bacterial community assembly

The paper identifies a latitudinal gradient in plant leaf-associated bacterial communities, showing host-driven selection at high latitudes and multiple factors at low latitudes.

Intestinal epithelial IPMK protects mice from experimental colitis via governing colonic tuft cell development

This study shows that IPMK in intestinal epithelial cells protects against colitis by regulating tuft cell development and cholinergic signaling.

The synergistic effect of circRNA methylation promotes pulmonary fibrosis

The paper identifies two circRNAs whose m6A methylation synergistically promotes pulmonary fibrosis by targeting eIF4A3, mediated by METTL3.

Exploration of clinical breakpoint of Danofloxacin for Glaesserella parasuis in plasma and in PELF

This study establishes three clinical breakpoint values for danofloxacin against Glaesserella parasuis using epidemiological, pharmacodynamic, and clinical data.

Inhibition of Anti-viral Stress Granule Formation by infectious bronchitis virus endoribonuclease nsp15 Ensures Efficient Virus Replication

This study shows that IBV uses nsp15 to inhibit stress granule formation, thereby evading antiviral responses and promoting viral replication.

IRGM/Irgm1 Aggravates Progression of Atherosclerosis by Inducing Macrophage Apoptosis through the MAPK Signaling Pathway

This study shows IRGM/Irgm1 worsens atherosclerosis by causing macrophage apoptosis via the MAPK pathway, increasing plaque vulnerability and risk of rupture.

Sequencing of clinical samples reveals that adaptation keeps establishing during H7N9 virus infection in humans

This study analyzes H7N9 virus genome mutations in human clinical samples to identify potential adaptations during infection.

A novel fermented Yi traditional medicine efficiently suppresses the replication of SARS-CoV-2 in vitro

This study investigates a fermented Yi traditional medicine, JB10, showing significant in vitro suppression of SARS-CoV-2 replication with EC50 of 769.1 dilutions and a selection index of 42.68.

Hsp22 is the key sensor and balancer in mitochondrial dynamic associated metabolic reprogramming

The paper shows that Hsp22 overexpression reverses metabolic reprogramming and pathogenic phenotypes in tumor and Parkinson's disease models by restoring mitochondrial homeostasis.

Longitudinal ultrasonic dimensions and parametric solid models of the gravid uterus and cervix

This study uses ultrasound imaging and biomechanical modeling to analyze uterine and cervical dimensions during pregnancy, providing reliable measurements for future computational biomechanical studies.

Identification of microbial markers across populations in early detection of colorectal cancer

The paper identifies microbial markers for early colorectal cancer detection across populations using meta-analysis and classifier models, achieving high diagnostic accuracy.

Alterations in bile acid metabolizing gut microbiota and specific bile acid genes as a precision medicine to subclassify NAFLD

The paper identifies bile acid metabolizing microbes and genes associated with NAFLD subtypes using metagenomic data and develops a classifier model for NAFLD detection.

Interleukin-22 mediated renal metabolic reprogramming via PFKFB3 to treat kidney injury

This study identifies IL-22's role in renal metabolic reprogramming through PFKFB3 to treat kidney injury in animal models.

SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damage and constitutes an antiviral target

This study shows the SARS-CoV-2 envelope protein causes ARDS-like damage and identifies channel inhibitors as potential antiviral targets.

Interleukin-22 drives a metabolic adaptive reprogramming to maintain mitochondrial fitness and treat liver injury

This study shows IL-22 improves liver injury by promoting metabolic reprogramming and mitochondrial function through a signaling pathway involving AMPK, AKT, and mTOR.