M. Ganji

Decoding the role of DNA sequence on protein-DNA co-condensation

This paper develops a polymer-based model to study how DNA sequence affects protein-DNA co-condensation, showing that sequence heterogeneity leads to multiple condensates.

Bridging DNA contacts allow Dps from E. coli to condense DNA

This study investigates how DNA topology influences the formation of Dps-DNA complexes, showing that DNA supercoils and bridging contacts facilitate nucleation and stabilization of these structures.

Bat RNA viruses employ viral RHIMs orchestrating species-specific cell death programs linked to Z-RNA sensing and ZBP1-RIPK3 signaling

The paper identifies viral RHIMs in bat RNA viruses that regulate host cell death through Z-RNA sensing and ZBP1-RIPK3 signaling, revealing species-specific effects on human and bat cells.

Cryo-EM reveals the mechanism of DNA compaction by Mycobacterium smegmatis Dps2

This study uses cryo-EM to reveal how MsDps2 binds and compacts DNA, identifying key arginine residues involved in DNA binding and lattice formation.

Single-Molecule Analysis of DNA Base-Stacking Energetics Using Patterned DNA Nanostructures

This study measures single-molecule dinucleotide base-stacking energies using DNA-PAINT and designer nanostructures, revealing stabilization effects and energy ranges for specific base pairs.

DNA sequence encodes the position of DNA supercoils

The paper shows DNA sequence encodes supercoil positions by pinning plectonemes, with intrinsic curvature over ~70 bp being key, and predicts plectonemes upstream of prokaryotic transcription start sites.