P. Garg

Computational Modeling of Hyperpolarizing Astrocytic Influence on Cortical Up-Down State Transitions

This paper introduces a computational model of cortical Up-Down dynamics incorporating hyperpolarizing astrocytes and identifies high- and low-sensitivity parameters through parameter optimization and stability analysis.

Host inducible-HSP70A1A is an irresistible drug target to combat SARS-CoV-2 infection and pathogenesis

This study shows that inhibiting host Hsp70 reduces SARS-CoV-2 infection more effectively than Remdesivir by blocking viral entry and autophagy.

Predicting the feasibility of targeting a conserved region on the S2 domain of the SARS-CoV-2 spike protein

The paper assesses the feasibility of targeting a conserved S2 epitope on the SARS-CoV-2 spike protein, finding it unlikely to be exposed without external factors and suggesting it may be a viable therapeutic target.

Genomic perspectives of SARS CoV-2 in liver disease patients with its clinical correlation: A single centre retrospective study

This study compares the mutational and clinical profiles of liver disease patients infected with different SARS CoV-2 variants, finding higher mortality risk and specific genetic mutations associated with adverse outcomes.

Cryo-EM reveals the mechanism of DNA compaction by Mycobacterium smegmatis Dps2

This study uses cryo-EM to reveal how MsDps2 binds and compacts DNA, identifying key arginine residues involved in DNA binding and lattice formation.

Ancestral SARS-CoV-2 driven antibody repertoire diversity in an unvaccinated individual correlates with expanded neutralization breadth

The paper examines antibody diversity in an unvaccinated SARS-CoV-2 infected individual, finding that post-vaccination neutralization breadth against Omicron variants is comparable to vaccinated individuals and breakthrough infections.

Notch-1 mediates Epithelial-Mucosal Healing during Murine Colitis Recovery Phase

This study investigates the role of Notch-1 signaling in colonic epithelial healing during colitis recovery in mice, finding that its deletion impairs mucosal repair.

Elucidating the structural features of ABCA1 in its heterogeneous membrane environment.

This study uses molecular dynamics simulations to characterize ABCA1's conformation and lipid interactions in a heterogeneous membrane environment, revealing a continuous tunnel that supports the lateral access theory.

Comparative immunogenicity of bacterially expressed soluble trimers and nanoparticle displayed influenza hemagglutinin stem immunogens

This study compares the immunogenicity of soluble trimeric influenza stem domain immunogens and nanoparticle-displayed versions, showing similar protection against homologous and heterologous viral challenges.

SARS-CoV-2 Spike Glycoprotein and ACE2 interaction reveals modulation of viral entry in wild and domestic animals

This study evaluates the interaction between SARS-CoV-2 spike protein and ACE2 receptors across species to predict viral entry probabilities in different animals.

In Silico Determined Properties of Designed Superoxide Dismutase-1 Mutants Predict ALS-like Phenotypes In Vitro and In Vivo

The paper designs and tests SOD1 mutants using computational methods, showing that a destabilizing mutant causes ALS-like phenotypes while a stabilizing mutant rescues them in zebrafish.