Author

M. Gozdecka

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Assay:ChIP-seq· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1

Frequent Co-Authors

G. S. Vassiliou· 3 shared B. J. P. Huntly· 2 shared G. Giotopoulos· 2 shared O. M. Dovey· 2 shared A. Castillo-Venzor· 1 shared A. F. Domingues· 1 shared A. Mupo· 1 shared B. Huntly· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersCancer Biology

G. S. Vassiliou

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3 papers

Recent·Most cited

Transcriptional variability accelerates pre-leukemia by cell diversification and perturbation of protein synthesis

S. Gupta, O. M. Dovey, A. F. Domingues, O. W. Cyran, C. M. Cash, G. Giotopoulos, J. Rak, J. Cooper, M. Gozdecka, R. J. Asby, N. Al-Jabery, V. Hernandez-Hernandez, S. Prabakaran, B. Huntly, G. S. Vassiliou, C. Pina

Loss of Kat2a enhances transcriptional variability of ribosome biosynthetic programs and transiently accelerates pre-leukemia.

bioRxiv · Oct 18, 2021 · PreprintCancer Biology

KAT7 is a therapeutic vulnerability of MLL-rearranged acute myeloid leukemia

Y. Z. Au, M. Gu, E. De Braekeleer, J. S. L. Yu, S. H. Ong, M. Gozdecka, X. Chen, K. Tzelepis, B. J. P. Huntly, G. S. Vassiliou, K. Yusa

This study identifies KAT7 as a critical therapeutic target in MLL-rearranged AML by showing its role in maintaining acetylation marks and supporting cell proliferation.

bioRxiv · Apr 25, 2020 · PreprintCancer Biology

Mutational synergy coordinately remodels chromatin accessibility, enhancer landscape and 3-Dimensional DNA topology to alter gene expression during leukemia induction

H. Yun, S. Vohra, A. Mupo, G. Giotopoulos, D. Sasca, S. J. Horton, S. Agrawal-Singh, E. Meduri, F. Basheer, L. Marando, M. Gozdecka, O. M. Dovey, A. Castillo-Venzor, X. Wang, P. Gallipoli, , B. J. P. Huntly

The paper investigates how mutations synergize to alter chromatin accessibility, enhancer landscapes, and 3D DNA topology in leukemia induction using a murine model.

bioRxiv · Mar 20, 2020Cancer Biology