T. Mori

The priming phosphorylation of KaiC is activated by the release of its autokinase autoinhibition

This study identifies the autoinhibition mechanism of KaiC priming phosphorylation and shows how KaiA relieves this inhibition by altering R385 interactions.

A non-toxic equinatoxin-II reveals the dynamics of sphingomyelin in the cytosolic leaflet of the plasma membrane

The paper uses a non-toxic SM probe to show dynamic SM and cholesterol domains in the cytosolic leaflet of plasma membranes.

Label-free visualization and quantification of the drug-type-dependent response of tumor spheroids by dynamic optical coherence tomography

This study uses dynamic optical coherence tomography to quantify tumor spheroid responses to three anti-cancer drugs, showing drug-specific structural and signal changes over time.

Structure and function of bacterial YeeE-YeeD complex in thiosulfate uptake pathway

This study investigates the YeeE-YeeD complex in thiosulfate uptake, showing YeeD's role in transport and decomposition, and presents their structural interactions.

Genome-wide association studies of seed metabolites identify loci controlling specialized metabolites in Arabidopsis thaliana

This study uses GWAS and QTL mapping to identify genetic loci controlling specialized metabolites in Arabidopsis thaliana seeds.

Genesis of Ecto-symbiotic features based on Commensalistic Syntrophy

This study explores the evolutionary origin of ecto-symbiotic features through a commensalistic syntrophy model, hypothesizing a single mutation initiated host-symbiont interactions.

Human immune and gut microbial parameters associated with inter-individual variations in COVID-19 mRNA vaccine-induced immunity

The paper identifies baseline AP-1 gene expression and gut microbial fucose/rhamnose degradation as factors negatively correlated with BNT162b2 mRNA vaccine-induced T-cell responses.

Validation of the Tea Bag Index as a standard approach for assessing organic matter decomposition

This study validates the Tea Bag Index (TBI) for assessing organic matter decomposition and finds that its assumptions about decomposition rates and carbon stability are not accurate in terrestrial ecosystems.

Single-cell metabolite detection and genomics reveals uncultivated talented producer

This study identifies an uncultivated bacterium as a producer of antifungal metabolites using Raman microscopy and single-cell sequencing in a sponge microbiome.

Does the ratio of β-1,4-glucosidase (BG) to β-1,4-N-acetylglucosaminidase (NAG) indicate the relative resource allocation of soil microbes to C and N acquisition?

This study tests whether the BG:NAG ratio reflects microbial C vs N allocation by analyzing N fertilization effects and decomposition stages.

The Inherent Flexibility of Receptor Binding Domains in SARS-CoV-2 Spike Protein

This study identifies multiple conformational states of the SARS-CoV-2 Spike protein's receptor binding domain through molecular dynamics simulations, highlighting structural flexibility important for drug and vaccine design.

Testing the Tea Bag Index as a potential indicator for assessing litter decomposition in aquatic ecosystems

The paper validates the Tea Bag Index method in aquatic ecosystems and finds it inaccurate due to non-plateauing decomposition and model discrepancies.

Protein-bound sialic acid in saliva contributes directly to salivary anti-influenza virus activity

This study identifies protein-bound sialic acid (BSA) as a determinant of individual variation in salivary anti-influenza virus activity.

Tandem mass spectrum similarity-based network analysis using 13C-labeled and non-labeled metabolome data to identify the biosynthesis pathway of the blood pressure-lowering asparagus metabolite asparaptine A

The paper identifies the biosynthesis pathway of asparaptine A using metabolome network analysis and shows its blood pressure-lowering effects in mice.

Evaluating the tea bag method as a potential tool for detecting the effects of added nutrients and their interactions with climate on litter decomposition

This study evaluates the tea bag method's ability to detect nutrient addition effects and their interaction with climate on litter decomposition, finding it effective for early-stage but not late-stage decomposition.

Spatial metabolomics using imaging mass spectrometry to identify the localization of asparaptine in Asparagus officinalis

The paper uses spatial metabolomics to locate asparaptine in asparagus spears, showing its accumulation in lateral shoots and validating findings with LC-MS/MS.

Multi-metabolomics using imaging mass spectrometry and liquid chromatography-tandem mass spectrometry for spatially characterizing monoterpene indole alkaloids secreted from roots

The paper uses imaging mass spectrometry and LC-MS/MS to spatially characterize monoterpene indole alkaloids released from plant roots in agar.

Emergence of artemisinin-resistant Plasmodium falciparum with kelch13 C580Y mutations on the island of New Guinea

The paper identifies the emergence of artemisinin-resistant Plasmodium falciparum with kelch13 C580Y mutations in Papua New Guinea and suggests an independent origin with distinct genetic features.

Effects of water content and mesh size on tea bag decomposition

This study examines how water content and mesh size affect tea bag decomposition rates in controlled and field settings, finding that decomposition increases with water content up to a point and that finer mesh sizes do not always reduce decomposition rates.

Implicit micelle model for membrane proteins using super-ellipsoid approximation

The paper introduces an implicit micelle model (IMIC) for MD simulations of membrane proteins, showing it provides accurate structure predictions with lower computational cost than explicit models.

Is microbial activity in tropical forests limited by phosphorus availability? Evidence from a tropical forest in China

This study investigates whether microbial activity in tropical forests is limited by phosphorus availability, finding that P addition increases soil respiration but suppresses litter decomposition due to organic carbon desorption.