S. Sato

Reducing stomatal density by expression of a synthetic EPF increases leaf intrinsic water use efficiency and reduces plant water use in a C4 crop

This study shows that reducing stomatal density in sorghum via synthetic EPF expression improves water use efficiency without compromising carbon fixation, but with trade-offs in reproductive development.

Interaction between Solo and PDZ-RhoGEF is involved in actin cytoskeletal remodeling and response to substrate stiffness

This study identifies PDZ-RhoGEF as an interacting partner of Solo, showing their role in actin cytoskeletal remodeling and response to substrate stiffness.

Epigenetic mechanisms to propagate histone acetylation by p300/CBP

This study identifies how p300/CBP reads and writes histone acetylation to propagate epigenetic marks and activate gene transcription.

Mesenchymal Progenitors set the homeostatic inflammatory milieu via the TAK1-NFkB axis.

This study shows mesenchymal progenitors regulate the balance between type 1 and type 2 inflammation via the TAK1-NFkB pathway, with implications for inflammatory diseases.

Empirical single-cell tracking and cell-fate simulation reveal dual roles of p53 in tumor suppression

This study uses single-cell tracking and simulation to show that p53 low levels suppress cell death and aneuploidy but also allow p53-deficient cells to expand under stress.

Genome analysis of Parmales, a sister group of diatoms, reveals the evolutionary specialization of diatoms from phago-mixotrophs to photoautotrophs

This study compares parmalean and diatom genomes to show diatoms evolved from phago-mixotrophs to photoautotrophs by losing phagocytosis genes and gaining silica and nutrient metabolism capabilities.

Indirect CRISPR screening with photoconversion revealed key factors of drug resistance with cell-cell interactions

This study uses indirect CRISPR screening with photoconversion to identify key factors of drug resistance mediated by cell-cell interactions, finding genes that reduce cancer cell apoptosis when knocked out in supporting cells.

Receptor-like kinases FER and SRK mediate Lotus japonicus freezing tolerance and climate adaptation

The paper identifies FER and SRK as genes involved in freezing tolerance and climate adaptation in Lotus japonicus.

Genotype by microbiome interactions have large effects on growth in Lotus japonicus

The paper investigates how plant genotype, soil microbiome, and environmental conditions interact to influence root microbiome composition and plant growth in Lotus japonicus.

Lipid-correlated alterations in the transcriptome are enriched in several specific pathways in the postmortem prefrontal cortex of Japanese patients with schizophrenia

The paper integrates transcriptome and lipidome data from postmortem prefrontal cortex samples of schizophrenia patients to identify lipid-correlated gene expression changes in specific pathways.

The rice OsERF101 transcription factor regulates the NLR Xa1-mediated perception of TAL effectors and Xa1-mediated immunity

This study identifies OsERF101 as a regulator of Xa1-mediated immunity in rice by interacting with TAL effectors and modulating immune responses.

Antihypertensive effect of brain-targeted mechanical intervention with passive head motion

Passive head motion reduces blood pressure in hypertensive rats and humans by decreasing AT1R expression in RVLM astrocytes through interstitial fluid shear stress.

DNA methylation site loss for plasticity-led novel trait genetic fixation

The paper investigates how epigenetic regulation loss leads to genetic fixation of novel traits in medaka fish through methylation profiling and CRISPR/Cas9 deletion.

NPC1L1 inhibition disturbs lipid trafficking and induces large lipid droplet formation in intestinal absorptive epithelial cells

This study shows that NPC1L1 inhibition reduces chylomicron assembly and secretion in intestinal cells by limiting cholesterol availability, leading to large lipid droplet formation.

Massive rhizobial genomic variations associated with partner quality in Lotus-Mesorhizobium symbiosis

The paper investigates how genetic variations in rhizobial symbionts affect partner quality in Lotus-Mesorhizobium symbiosis, finding that core genome variations, not symbiosis island genes, correlate with plant growth phenotypes.

Intragenic Complementation of Cellulose Synthase-Like D1 alleles in Root Hair Development

This study identifies and analyzes mutations in the CSLD1 gene in Lotus japonicus, showing their effects on root hair development and suggesting a potential role in root nodule symbiosis.

Integrated role of microRNA-30e-5p through targeting negative regulators of innate immune pathways during HBV infection and SLE

This study identifies miR-30e as a master regulator of innate immune responses during HBV infection and SLE, showing its role in modulating immune pathways and therapeutic potential.

Extracellular matrix mineralization in the mouse osteoblast-like cell line MC3T3-E1 is regulated by actin cytoskeleton reorganization and non-protein molecules secreted from the cells themselves

This study shows that actin cytoskeleton reorganization and non-protein molecules secreted by MC3T3-E1 cells regulate extracellular matrix mineralization during osteoblast differentiation.

Mapping of transgenic alleles in plants using a Nanopore-based sequencing strategy

The paper introduces a Nanopore-based sequencing method to rapidly map transgenic alleles in the soybean genome, offering a high-throughput and cost-efficient approach.

Extreme genetic signatures of local adaptation during plant colonization

The paper investigates genetic adaptations during the colonization of Japan by Lotus japonicus, identifying genomic regions and candidate genes associated with overwintering and flowering time traits.

Dose-dependent spatiotemporal responses of mammalian cells to an alkylating agent

This study uses single-cell lineage tracking to analyze spatiotemporal responses of HeLa cells to different doses of MNNG, revealing distinct cell fate outcomes.

A member of the ferlin calcium sensor family is essential for Toxoplasma gondii rhoptry secretion

This study identifies TgFER2, a Ca2+ sensor essential for rhoptry secretion in Toxoplasma gondii, which is required for host cell invasion.

Galectin-3 and N-acetylglucosamine promote myogenesis and improve skeletal muscle function in the mdx model of Duchenne muscular dystrophy

This study shows that galectin-3 and N-acetylglucosamine enhance myogenesis and improve muscle function in the mdx DMD mouse model.