Ketolysis is a metabolic driver of CD8+ T cell effector function through histone acetylation
K. M. Luda, S. M. Kitchen-Goosen, E. H. Ma, M. J. Watson, L. R. Duimstra, B. M. Oswald, J. Longo, Z. Fu, Z. Madaj, A. Kupai, B. M. Dickson, I. Kaymak, K. Lau, S. Compton, L. M. DeCamp, , R. G. Jones
This study identifies ketone bodies as essential for CD8+ T cell metabolism and effector function through histone acetylation regulation.
bioRxiv · Aug 26, 2022 · PreprintImmunology