Author

S. Compton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Microbiology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

C. M. Krawczyk· 2 shared K. Lau· 2 shared A. Kupai· 1 shared A. M. Ring· 1 shared A. R. VanderArk· 1 shared A. Swaminathan· 1 shared A. Wang· 1 shared B. K. Hilliard· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersImmunology

C. M. Krawczyk

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Author profile →

5 papers

Recent·Most cited

The histone lysine demethylase KDM5C fine-tunes gene expression to regulate dendritic cell heterogeneity and function

H. Guak, M. J. Weiland, A. R. VanderArk, L. Zhai, K. Lau, B. Mabvakure, M. Corrado, P. Davidson, S. Compton, L. DeCamp, C. Scullion, R. M. Jones, S. Nowinski, C. M. Krawczyk

This study shows KDM5C regulates dendritic cell (DC) heterogeneity and function by modulating epigenetic programming and subset balance, affecting immune responses to infection.

bioRxiv · May 28, 2023 · PreprintImmunology

Lack of Fzd6 in Ciliated Cells Suppresses Ferroptotic Pulmonary Alveolar Cell Death Induced by LPS and Coronavirus

Q. Yuan, Y. Luan, B. K. Rajendran, S. Compton, W. Tang, D. Wu

This study shows that Fzd6 deficiency in ciliated cells reduces pulmonary inflammation-induced cell death by increasing Akr1b8 expression and protecting against ferroptosis.

bioRxiv · Jan 23, 2023 · PreprintPathology

SARS-CoV-2 exposure in Norway rats (Rattus norvegicus) from New York City

Y. Wang, J. Lenoch, D. Kohler, T. DeLiberto, C. Tang, T. Li, Y. Tao, M. Guan, S. Compton, C. J. Zeiss, J. Hang, X.-F. Wan

The paper tests SARS-CoV-2 exposure in NYC rats, finding 16.5% seropositive and partial genomes in some, and shows rat susceptibility to Alpha, Delta, and Omicron variants.

bioRxiv · Nov 18, 2022Microbiology

Ketolysis is a metabolic driver of CD8+ T cell effector function through histone acetylation

K. M. Luda, S. M. Kitchen-Goosen, E. H. Ma, M. J. Watson, L. R. Duimstra, B. M. Oswald, J. Longo, Z. Fu, Z. Madaj, A. Kupai, B. M. Dickson, I. Kaymak, K. Lau, S. Compton, L. M. DeCamp, , R. G. Jones

This study identifies ketone bodies as essential for CD8+ T cell metabolism and effector function through histone acetylation regulation.

bioRxiv · Aug 26, 2022 · PreprintImmunology

Type I Interferon Limits Viral Dissemination-Driven Clinical Heterogeneity in a Native Murine Betacoronavirus Model of COVID-19

H. Qing, L. Sharma, B. K. Hilliard, X. Peng, A. Swaminathan, J. Tian, K. Israni-Winger, C. Zhang, D. Leao, S. Ryu, V. Habet, L. Wang, X. Tian, S. Ishibe, L. H. Young, , A. Wang

This study establishes a murine model of COVID-19 using MHV-A59 and shows that type-I interferons limit viral dissemination, reducing lethality and recapitulating key clinical features.

bioRxiv · Sep 11, 2020 · PreprintImmunology