Z. Fu

scCancerExplorer: a comprehensive database for interactively exploring single-cell multi-omics data of human pan-cancer

scCancerExplorer provides an interactive database for exploring single-cell multi-omics data across 50 cancer types, integrating genomic, epigenomic, and transcriptomic data.

NRF2-dependent regulation of the prostacyclin receptor PTGIR drives CD8 T cell exhaustion

This study identifies the KEAP1-NRF2 pathway as a driver of CD8 T cell exhaustion by regulating the prostacyclin receptor PTGIR.

An epilepsy-associated CILK1 variant compromises KATNIP regulation and impairs primary cilia and Hedgehog signaling

This study shows that a CILK1 variant linked to epilepsy impairs primary cilia and Hedgehog signaling by disrupting KATNIP regulation in mouse cells.

Structure of the Flotillin Complex in a Native Membrane Environment

This study determines the structure of the Flotillin complex in a native membrane environment using cryo-electron microscopy, revealing its role in membrane curvature and isolation of biochemical processes.

Potential clinical value and influence of conductivity in conductive cardiac patches for reducing post-MI arrythmia risks

This study evaluates the clinical value of conductive cardiac patches by testing different conductivities and shows that higher conductivity reduces arrhythmia risks in post-MI hearts.

Association between the oral microbiome and brain resting state connectivity in schizophrenia

This study investigates the association between oral microbiome composition and brain functional connectivity in schizophrenia, finding significant microbiome shifts and correlations with brain network alterations.

DNA sensor ABCF1 phase separates with cccDNA to inhibit HBV replication

This study identifies ABCF1 as a host protein that interacts with cccDNA, forming phase-separated condensates to suppress HBV replication through innate immune activation and transcription inhibition.

CLAIR: An integrated lipid database across multiple crop species

The paper constructs a comprehensive lipid metabolism gene database for nine oilseed crops by integrating multi-omics data and identifying 221 additional genes.

Rapid evolution of pesticide resistance via adaptation and interspecific introgression in a major North American crop pest

This study identifies two mechanisms of rapid pesticide resistance evolution in Helicoverpa zea: introgression from H. armigera and intraspecific adaptation.

TRIM72 restricts lyssavirus infection by inducing K48-linked ubiquitination and proteasome degradation of the matrix protein

This study identifies TRIM72 as a host factor that restricts lyssavirus infection by promoting ubiquitination and proteasomal degradation of the viral matrix protein.

Nucleoporin-binding nanobodies that either track or inhibit nuclear pore complex assembly

The paper introduces nanobodies that track or inhibit nuclear pore complex (NPC) assembly by targeting Nups and solving challenges in NPC detection and assembly inhibition.

Cryo-EM studies of the four E. coli paralogs establish ABCF proteins as master plumbers of the peptidyl-transferase center of the ribosome

This study presents cryo-EM structures of four E. coli ABCF paralogs bound to the ribosome, revealing their role in modulating tRNA geometry and catalytic function at the peptidyl-transferase center.

Cryo-EM of α-tubulin isotype containing microtubules revealed a contracted structure of α4A/β2A microtubules

The paper determines cryo-EM structures of microtubules composed of different α-tubulin isotypes and finds that α4A/β2A microtubules show longitudinal contraction compared to other isotype combinations.

Cis-regulatory evolution of the potassium channel gene kcnj13 during pigment pattern diversification in Danio fish

This study identifies cis-regulatory changes in kcnj13 as the cause of pigment pattern divergence between Danio rerio and Danio aesculapii.

Maximum Classifier Discrepancy Generative Adversarial Network for Jointly Harmonizing Scanner Effects and Improving Reproducibility of Downstream Tasks

This paper introduces MCD-GAN, a method that harmonizes scanner effects in MRI data while preserving biological information, improving cross-scanner classification performance.

Mechanism of dual pharmacological correction and potentiation of human CFTR

This paper uses cryo-EM to reveal how VX445 corrects CFTR folding and gating defects by altering allosteric communication pathways.

Ketolysis is a metabolic driver of CD8+ T cell effector function through histone acetylation

This study identifies ketone bodies as essential for CD8+ T cell metabolism and effector function through histone acetylation regulation.

Elastic properties and shape of the Piezo dome underlying its mechanosensory function

The paper determines the force-distortion relationship of Piezo channels using vesicle shape measurements and derives their intrinsic curvature and bending stiffness.

Quantitative prediction and measurement of Piezo's membrane footprint

The paper predicts and measures the membrane footprint of Piezo proteins using elasticity theory and cryo-electron tomography, showing agreement across vesicle sizes and revealing a spherical cap geometry.

Therapeutic activation of endothelial sphingosine 1-phosphate receptor-1 by chaperone-bound S1P suppresses proliferative retinal vasculopathy

The paper shows that activating endothelial S1PR1 with HDL-bound S1P or a Gi-biased agonist suppresses neovascular tufts in retinopathy models.

Two interacting transcriptional coactivators cooperatively control plant immune responses

This study identifies NPR1 and EDS1 as interacting coactivators that synergistically activate PR genes and plant defenses through Mediator complex recruitment and mutual stabilization.

An updated assembly strategy helps parsing the cryptic mitochondrial genome evolution in plants

The paper develops a new assembly strategy to improve mitogenome reconstruction in plants, revealing mosaic structures and horizontal transfer contributions to mitochondrial evolution.

Molecular mechanism of ACAD9 in mitochondrial respiratory complex 1 assembly

This study investigates the molecular mechanism of ACAD9 in mitochondrial respiratory complex 1 assembly, revealing its dual role as a chaperone and its structural interactions with ECSIT and NDUFAF1.

Target lipidomics reveals associations between serum sphingolipids and insulin sensitivity by the glucose clamp

This study identifies serum sphingolipids associated with insulin sensitivity using lipidomics and glucose clamp techniques, finding SM/Cer and SM d18:0/26:0 as potential biomarkers.

Intracellular accumulation and secretion of hydrophobin-enriched vesicles aid the rapid sporulation of molds

The paper investigates the role of hydrophobin-enriched vesicles in mold sporulation, showing their intracellular accumulation and secretion contribute to spore hydrophobicity and rapid sporulation.

Structural basis for the inhibition of the papain-like protease of SARS-CoV-2 by small molecules

The paper identifies GRL0617 as a non-covalent inhibitor of SARS-CoV-2 PLpro with an IC50 of 2.1 μM, supported by co-crystal and NMR data showing its mechanism of action.

Type I interferon responses to ischemic injury begin in the bone marrow of mice and humans and depend on Tet2, Nrf2, and Irf3

The paper shows type I interferon responses to ischemic injury start in the bone marrow of mice and humans, involving Tet2, Nrf2, and Irf3, and identifies ISG scores as a clinical biomarker.

Maize EHD1 is Required for Kernel Development and Vegetative Growth through Regulating Auxin Homeostasis

This study identifies ZmEHD1's role in maize kernel development and growth by regulating auxin homeostasis through clathrin-mediated endocytosis.

Distinct architecture and composition of mouse axonemal radial spoke head revealed by cryo-EM

The paper reveals the structure and composition of the mouse axonemal radial spoke head using cryo-EM, showing distinct subunit composition and organization compared to Chlamydomonas.

The structural basis for release factor activation during translation termination revealed by time-resolved cryogenic electron microscopy

This paper uses time-resolved cryo-EM to directly observe the transition of bacterial release factors RF1 and RF2 from a compact to extended conformation during translation termination.