Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
9 papers
Recent·Most cited
Q. Dowling, Y.-J. Park, N. Gerstenmaier, E. Yang, A. Wargacki, Y. Hsia, C. Fries, R. Ravichandran, C. Walkey, A. Burrell, D. Veesler, D. Baker, N. King
The paper designs large pseudosymmetric protein nanoparticles using a hierarchical computational method, achieving sizes up to 96 nm with 960 subunits.
bioRxiv · Jun 16, 2023 · PreprintBioengineering
A. Roy, L. Shi, A. Chang, X. Dong, A. Fernandez, J. C. Kraft, J. Li, V. Q. Le, R. V. Winegar, G. M. Cherf, D. Slocum, P. D. Poulson, G. E. casper, M. L. Vallecillo-Zuniga, J. C. Valdoz, , D. Baker
This paper designs highly selective miniprotein inhibitors for integrins αvβ6 and αvβ8 with picomolar affinity and therapeutic potential in a mouse fibrosis model.
bioRxiv · Jun 12, 2023 · PreprintBiochemistry
D. Ellis, N. Brunette, K. H. D. Crawford, A. C. Walls, M. N. Pham, C. Chen, K.-L. Herpoldt, B. Fiala, M. Murphy, D. Pettie, J. C. Kraft, K. D. Malone, M. J. Navarro, C. Ogohara, E. Kepl, , N. P. King
This paper designs stabilized SARS-CoV-2 RBD variants using deep mutational scanning and structure-based design, showing improved thermal stability and manufacturability for vaccine applications.
bioRxiv · May 15, 2021Microbiology
A. C. Walls, M. C. Miranda, M. N. Pham, A. Schaefer, A. Greaney, P. S. Arunachalam, M.-J. Navarro, M. A. Tortorici, K. Rogers, M. A. O'Connor, L. Shireff, D. E. Ferrell, N. Brunette, E. Kepl, J. E. Bowen, , Veesler
This study shows that a SARS-CoV-2 RBD nanoparticle vaccine protects against SARS-CoV-2 and related sarbecoviruses, including variants, in mice and non-human primates.
bioRxiv · Mar 15, 2021Immunology
J. B. Case, R. E. Chen, L. Cao, B. Ying, E. S. Winkler, I. Goreshnik, S. Shrihari, N. M. Kafai, A. L. Bailey, X. Xie, P.-Y. Shi, R. Ravichandran, L. Carter, L. Stewart, D. Baker, M. S. Diamond
This study evaluates the protective efficacy of modified miniproteins against SARS-CoV-2 in mice, showing reduced viral burden and prevention of lung disease.
bioRxiv · Mar 1, 2021Microbiology
P. J. M. Brouwer, A. Antanasijevic, M. de Gast, J. D. Allen, J. D. Allen, T. P. L. Bijl, A. Yasmeen, R. Ravichandran, J. Burger, G. Ozorowski, J. L. Torres, C. LaBranche, D. Montefiori, R. P. Ringe, M. van Gils, , R. W. Sanders
This study shows that displaying HIV-1 Env trimers on two-component protein nanoparticles enhances autologous Tier-2 neutralizing antibody titers in rabbits.
bioRxiv · Nov 30, 2020Microbiology
P. J. M. Brouwer, M. Brinkkemper, P. Maisonnasse, N. Dereuddre-Bosquet, M. Grobben, M. Claireaux, M. de Gast, R. Marlin, V. Chesnais, S. Diry, J. D. Allen, Y. Watanabe, J. M. Griezen, G. Kerster, H. L. Turner, , de Bree
This paper develops a two-component spike nanoparticle vaccine that protects macaques from SARS-CoV-2 infection by inducing strong neutralizing antibodies and reducing viral replication.
bioRxiv · Nov 7, 2020Immunology
A. C. Walls, B. Fiala, A. Schaefer, S. Wrenn, M. N. Pham, M. Murphy, L. V. Tse, L. Shehata, M. A. O'Connor, C. Chen, M. J. Navarro, M. C. Miranda, D. Pettie, R. Ravichandran, J. C. Kraft, , N. P. King
This study designs SARS-CoV-2 nanoparticle vaccines that induce strong neutralizing antibodies in mice, with higher titers and lower doses than existing trimer vaccines.
bioRxiv · Aug 11, 2020Immunology
S. Boyoglu-Barnum, D. Ellis, R. A. Gillespie, G. B. Hutchinson, Y.-J. Park, S. M. Moin, O. Acton, R. Ravichandran, M. Murphy, D. Pettie, N. Matheson, L. Carter, A. Creanga, M. J. Watson, S. Kephart, , M. Kanekiyo
Nanoparticle immunogens with four seasonal influenza hemagglutinins elicit neutralizing antibodies against both the head and stem, providing broad protection against diverse influenza strains.
bioRxiv · May 30, 2020 · PreprintImmunology