M. K. Saito

This study uses patient-derived iPSCs to identify retinoids as potential therapeutics for Wilson's disease by rescuing ceruloplasmin secretion and reducing oxidative stress.

This study shows SMN regulates mitochondrial metabolic maturation during myogenesis by controlling the MYOD-miRNA axis, with miR-1 and miR-206 supplementation restoring mitochondrial function in SMN-deficient cells.

This paper predicts chemical toxicities using induced pluripotent stem cells and gene networks via transfer learning from embryonic stem cell data, achieving high accuracy across multiple toxicity categories.

This study identifies that CDC42 C-terminal variants cause aberrant Golgi localization, leading to pyrin inflammasome activation and autoinflammation.

The paper develops a microfluidic AGM-on-a-chip to study human developmental hematopoiesis and demonstrates its ability to induce endothelial-to-hematopoietic transition.