M. Kasper

Cancer associated fibroblast subtypes modulate the tumor-immune microenvironment and are associated with skin cancer malignancy

This study identifies three CAF subtypes in skin cancers and shows their association with tumor malignancy and immune modulation.

Skin mesenchymal niches maintain and protect AML-initiating stem cells

The paper shows skin mesenchymal niches protect AML-initiating stem cells from chemotherapy and promote chemoresistance in a mouse model.

Rare Gli1+ perivascular fibroblasts promote skin wound repair

The paper identifies Gli1+ perivascular fibroblasts as a key cell source for wound healing, showing their role in myofibroblast differentiation and wound contraction.

Injury suppresses Ras cell competitive advantage through enhanced wild-type cell proliferation

Injury-repair selectively induces wild-type cell proliferation to suppress oncogenic growth in Ras-mosaic skin epithelium.

Intra-ocular dendritic cells are increased in HLA-B27 associated acute anterior uveitis

The paper characterizes intraocular leukocyte infiltration in HLA-B27-associated uveitis using scRNA-seq, flow cytometry, and proteomics, revealing a unique dendritic cell infiltration pattern.

Gradual differentiation uncoupled from cell cycle exit generates heterogeneity in the epidermal stem cell layer.

The paper shows that epidermal stem cells undergo gradual differentiation without exiting the cell cycle, generating heterogeneity in the stem cell layer.

The molecular anatomy of mouse skin during hair growth and rest

The paper creates a comprehensive single-cell transcriptome atlas of mouse skin during hair growth and rest, identifying key cell populations and their molecular and spatial organization.